Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells

• Material Type: 博士論文
• ISSN: 0304-3835
• Title: Bone marrow-derived fibrocytes promote stem cell-like properties of lung cancer cells
• Volume: 421
• Author/Editor: Saijo, Atsuro; Goto, Hisatsugu; Nakano, Mayuri; Mitsuhashi, Atsushi; Aono, Yoshinori; Hanibuchi, Masaki; Ogawa, Hirohisa; Uehara, Hisanori; Kondo, Kazuya; Nishioka, Yasuhiko
• Author Heading: Saijo, Atsuro; Goto, Hisatsugu; Nakano, Mayuri; Mitsuhashi, Atsushi; Aono, Yoshinori; Hanibuchi, Masaki; Ogawa, Hirohisa; Uehara, Hisanori; Kondo, Kazuya; Nishioka, Yasuhiko
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-02-12
• Publication Date (W3CDTF): 2018-02-12
• Alternative Title: 骨髄由来線維細胞は肺がん細胞のがん幹細胞様特性を増強する
• Periodical title: Cancer Letters
• Degree grantor/type: 徳島大学
• Date Granted: 2018-03-20
• Date Granted (W3CDTF): 2018-03-20
• Dissertation Number: 甲第3131号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3131号
• Text Language Code: eng
• Subject Heading: Lung cancer; Cancer stem cell; Fibrocyte; Tumor microenvironment; AKT pathway
• Target Audience: 一般
• Note (General): Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14þ monocytes and have features of both macrophages and fibroblasts. Accumulating evidence has suggested that stromal fibrocytes might promote cancer progression. However, the role of fibrocytes in the CSC niches has not been revealed. We herein report that human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.
• DOI: info:doi/10.1016/j.canlet.2018.02.016; https://doi.org/info:doi/10.1016/j.canlet.2018.02.016
• Persistent ID (NDL): info:ndljp/pid/11092346; https://dl.ndl.go.jp/pid/11092346
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://repo.lib.tokushima-u.ac.jp/111437
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp