Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying.

• Material Type: 博士論文
• ISSN: 1422-0067
• Title: Acute Effect of Metformin on Postprandial Hypertriglyceridemia through Delayed Gastric Emptying.
• Volume: 18 6
• Author/Editor: SATO, Daisuke
• Author Heading: SATO, Daisuke
• Publication, Distribution, etc.: MDPI
• Publication Date: 2017-06-16
• Publication Date (W3CDTF): 2017-06-16
• Periodical title: International Journal of Molecular Sciences
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2017-09-13
• Date Granted (W3CDTF): 2017-09-13
• Dissertation Number: 甲第791号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第791号
• Text Language Code: eng
• Subject Heading: Metformin; postprandial hypertriglyceridemia; gastric emptying
• Target Audience: 一般
• Note (General): Postprandial hypertriglyceridemia is a potential target for cardiovascular disease prevention in patients with diabetic dyslipidemia. Metformin has been reported to reduce plasma triglyceride concentrations in the postprandial states. However, little is known about the mechanisms underlying the triglyceride-lowering effect of metformin. Here, we examined the effects of metformin on lipid metabolism after olive oil-loading in 129S mice fed a high fat diet for three weeks. Metformin administration (250 mg/kg) for one week decreased postprandial plasma triglycerides. Pre-administration (250 mg/kg) of metformin resulted in a stronger triglyceride-lowering effect (approximately 45% lower area under the curve) than post-administration. A single administration (250 mg/kg) of metformin lowered plasma postprandial triglycerides comparably to administration for one week, suggesting an acute effect of metformin on postprandial hypertriglyceridemia. To explore whole body lipid metabolism after fat-loading, stomach size, fat absorption in the intestine, and fat oxidation (13C/12C ratio in expired CO₂ after administration of glyceryl-1-13C tripalmitate) were measured with and without metformin (250 mg/kg) pre-treatment. In metformin-treated mice, larger stomach size, lower fat oxidation, and no change in lipid absorption were observed. In conclusion, metformin administration before fat loading reduced postprandial hypertriglyceridemia, most likely by delaying gastric emptying.; Thesis or Dissertation; 平成29年度; 10.3390/ijms18061282
• DOI: info:doi/10.3390/ijms18061282; https://doi.org/info:doi/10.3390/ijms18061282
• Persistent ID (NDL): info:ndljp/pid/11092364; https://dl.ndl.go.jp/pid/11092364
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Date Created (W3CDTF): 2018-04-19
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/00012406; https://shiga-med.repo.nii.ac.jp/records/3268
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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