Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study.

• Material Type: 博士論文
• ISSN: 2072-6643
• Title: Bifidobacterium bifidum OLB6378 Simultaneously Enhances Systemic and Mucosal Humoral Immunity in Low Birth Weight Infants: A Non-Randomized Study.
• Volume: 9 3
• Author/Editor: TANAKA, Katsunori
• Author Heading: TANAKA, Katsunori
• Publication, Distribution, etc.: MDPI Publishing
• Publication Date: 2017-02-26
• Publication Date (W3CDTF): 2017-02-26
• Periodical title: Nutrients
• Degree grantor/type: 滋賀医科大学
• Date Granted: 2017-09-13
• Date Granted (W3CDTF): 2017-09-13
• Dissertation Number: 乙第431号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第431号
• Text Language Code: eng
• Subject Heading: probiotics; heat-treated; non-live bacteria; humoral immunity; sepsis; serum IgG; stool secretory IgA
• Target Audience: 一般
• Note (General): Probiotic supplementation has been part of the discussion on methods to enhance humoral immunity. Administration of Bifidobacterium bifidum OLB6378 (OLB6378) reduced the incidence of late-onset sepsis in infants. In this non-randomized study, we aimed to determine the effect of administration of live OLB6378 on infants' humoral immunity. Secondly, we tried to elucidate whether similar effects would be observed with administration of non-live OLB6378. Low birth weight (LBW) infants weighing 1500-2500 g were divided into three groups: Group N (no intervention), Group L (administered live OLB6378 concentrate), and Group H (administered non-live OLB6378 concentrate). The interventions were started within 48 h after birth and continued until six months of age. Serum immunoglobulin G (IgG) levels (IgG at one month/IgG at birth) were significantly higher in Group L than in Group N (p < 0.01). Group H exhibited significantly higher serum IgG levels (p < 0.01) at one month of age and significantly higher intestinal secretory immunoglobulin A (SIgA) levels (p < 0.05) at one and two months of age than Group N. No difference was observed in the mortality or morbidity between groups. Thus, OLB6378 administration in LBW infants enhanced humoral immunity, and non-live OLB6378, which is more useful as a food ingredient, showed a more marked effect than the viable bacteria.; Thesis or Dissertation; 平成29年度; 10.3390/nu9030195
• DOI: info:doi/10.3390/nu9030195; https://doi.org/info:doi/10.3390/nu9030195
• Persistent ID (NDL): info:ndljp/pid/11092366; https://dl.ndl.go.jp/pid/11092366
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-05-04T12:13:37+09:00
• Date Created (W3CDTF): 2018-04-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10422/00012408; https://shiga-med.repo.nii.ac.jp/records/3270
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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