Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma

• Material Type: 博士論文
• Title: Clinical Roles of Interleukin-6 and STAT3 in Oral Squamous Cell Carcinoma
• Volume: 23 2
• Author/Editor: 品川, 兼一
• Author Heading: 品川, 兼一
• Publication, Distribution, etc.: Springer Netherlands
• Publication Date: 2017-03-21
• Publication Date (W3CDTF): 2017-03-21
• Alternative Title: 口腔扁平上皮癌におけるInterleukin-6とSTAT3の臨床的役割
• Periodical title: Pathology & Oncology Research
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2017-03-21
• Date Granted (W3CDTF): 2017-03-21
• Dissertation Number: 甲医歯薬第921号
• Degree Type: 博士(歯学)
• Conferring No. (Dissertation): 甲医歯薬第921号
• Text Language Code: eng
• Subject Heading: Il-6; STAT3; Oral squamous cell carcinoma; Lymphangiogenesis
• Target Audience: 一般
• Note (General): The effect inflammation has on cancer prognosis is marked by the presence of cytokines and chemokines. Interleukin-6 (IL-6) is one a multifunctional cytokine that regulates inflammatory responses. We investigated the roles of IL-6 and STAT3 and examined the relationship between IL-6 signaling and clinicopathological factors in patients with oral squamous cell carcinoma (OSCC). We retrospectively examined 116 patients who underwent radical surgery for OSCC. IL-6 and STAT3 expression were detected by immunohistochemistry. IL-6 and STAT3 positivity were detected by IHC, at 78.4 and 80.2 %, respectively. IL-6 expression was significantly associated with pattern of invasion (P = 0.004), vascular invasion (P = 0.003), and pathological nodal status (P = 0.019). Multivariate logistic regression analysis revealed that IL-6 expression was significantly associated with vascular invasion (P = 0.044). Meanwhile, there was no significant association between STAT3 expression and clinicopathological factors and no significant relationship between IL-6 and STAT3 expression. IL-6 expression was significantly associated with 5-year disease-free survival. These results suggest that IL-6 is involved in lymphangiogenesis and recurrence in OSCC.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第921号 学位授与年月日:平成29年3月21日; Author: Kenichi Shinagawa, Souichi Yanamoto, Tomofumi Naruse, Akiko Kawakita, Kota Morishita, Yuki Sakamoto, Satoshi Rokutanda, Masahiro Umeda; Citation: Pathology & Oncology Research, 23(2), pp.425-431; 2017; Nagasaki University (長崎大学), 博士(歯学) (2017-03-21)
• DOI: info:doi/10.1007/s12253-016-0134-x; https://doi.org/info:doi/10.1007/s12253-016-0134-x
• Persistent ID (NDL): info:ndljp/pid/11098743; https://dl.ndl.go.jp/pid/11098743
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-06-04T01:14:06+09:00
• Date Created (W3CDTF): 2020-12-21
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/37282; https://nagasaki-u.repo.nii.ac.jp/records/2087
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2021-03-07 再収集