Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium. 12

• Material Type: 博士論文
• Title: Phenotypic characterization of adenomyosis occurring at the inner and outer myometrium.
• Volume: 12 12
• Author/Editor: Kishi, Yohei; Shimada, Keiji; Fujii, Tomomi; Uchiyama, Tomoko; Yoshimoto, Chiharu; Konishi, Noboru; Ohbayashi, Chiho; Kobayashi, Hiroshi
• Author Heading: Kishi, Yohei; Shimada, Keiji; Fujii, Tomomi; Uchiyama, Tomoko; Yoshimoto, Chiharu; Konishi, Noboru; Ohbayashi, Chiho; Kobayashi, Hiroshi
• Publication, Distribution, etc.: Public Library of Science
• Publication Date: 2017-12-18; 12 12
• Publication Date (W3CDTF): 2017-12-18
• Alternative Title: 子宮筋層の内外層に発生する子宮腺筋症おける、それぞれの組織学的特徴
• Periodical title: PloS one
• Pages: e0189522-
• ISSN (Periodical Title): 19326203
• Degree Grantor: 奈良県立医科大学
• Date Granted: 2018-03-15
• Date Granted (W3CDTF): 2018-03-15
• Dissertation Number: 甲第681号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第681号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): type:Thesis; OBJECTIVE: To estimate the phenotypic characterization of fibrotic process in adenomyosis occurring at the inner or the outer myometrium. METHODS: Eight cases of adenomyosis occurring at the inner myometrium (Subtype I) and 10 cases of adenomyosis occurring at the outer myometrium (Subtype II), and 10 normal counterparts were used in this study. A immunohistochemical study for smooth muscle cells (SMCs) was performed using cytoskeletal proteins, Type I and III collagen, TGF-β and its signaling molecules. RESULTS: An increased expression of Type I collagen was observed in the extracellular matrix of adenomyotic foci. In normal uteri, immunostaining of SMC differentiation marker proteins (Desmin, Smoothelin, Myosin heavy chain (MHC)) were absent or only found in low numbers at the inner myometrium, while all of these marker proteins were clearly stained at the outer myometrium. In both types of adenomyotic foci, Desmin, Smoothelin, and MHC commonly showed a negative staining at the adjacent area to the glands. A significant staining of Non-muscle myosin IIB, TGF-β, and phosphorylated TGF-β type I receptors were found only at the SMCs of Subtype II adenomyosis. The Smad3/2 ratio of Subtype II adenomyosis was significantly higher than that of Subtype I. CONCLUSIONS: The inner myometrium of normal uteri was composed of undifferentiated phenotypes of SMCs, while the outer myometrium was composed of terminally differentiated SMCs. Various fibrotic processes have been suggested in the development of uterine adenomyosis. Distinct expression patterns of fibrosis related proteins have been shown to be implicated with differences in the subtypes of adenomyosis.; 博士（医学）・甲第681号・平成30年3月15日; Copyright: © 2017 Kishi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.; identifier:PloS one Vol.12 No.12 Article No.e0189522 (2017 Dec); identifier:19326203; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3426; identifier:PloS one, 12(12): e0189522
• Persistent ID (NDL): info:ndljp/pid/11098855; https://dl.ndl.go.jp/pid/11098855
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-06-04T01:14:06+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Related Material (URI): https://doi.org/10.1371/journal.pone.0189522
• Periodical Title (URI): http://hdl.handle.net/10564/3426
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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