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Studies on molecular epidemiology of methicillinresistant Staphylococcus aureus originated from livestock animals, meat products, and humans
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- Sato, Tomomi
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- 2018-03-31
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- å é²åœã«ãããæ°èŠæèè¬ã®éçºãåæ»ããŠããäžæ¹ãããã«å¯Ÿããæèè¬ã®äžé©åãªäœ¿çšãèæ¯ãšããŠæ°ããªè¬å€èæ§èãå¢å ããŠããããã®ããè¬å€èæ§èã®åºçŸãšæ¡æ£ã¯äžççè åšãšãªã£ãŠãã察çãå¿ èŠãšãããŠãããããã«å»ççŸå Žã ãã§ãªãã家çã«å¯ŸããŠãå€ãã®æèè¬ãæ²»çããã³æé·ä¿é²ç®çãšããŠäœ¿çšããããã...
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- Sato, Tomomi
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- 2018-03-31
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- 家çãé£èãããã³ããç±æ¥MRSAã®ååç«åŠã«é¢ããç 究
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- é ªèŸ²åŠå倧åŠ
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- 2018-03-31
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- å é²åœã«ãããæ°èŠæèè¬ã®éçºãåæ»ããŠããäžæ¹ãããã«å¯Ÿããæèè¬ã®äžé©åãªäœ¿çšãèæ¯ãšããŠæ°ããªè¬å€èæ§èãå¢å ããŠããããã®ããè¬å€èæ§èã®åºçŸãšæ¡æ£ã¯äžççè åšãšãªã£ãŠãã察çãå¿ èŠãšãããŠãããããã«å»ççŸå Žã ãã§ãªãã家çã«å¯ŸããŠãå€ãã®æèè¬ãæ²»çããã³æé·ä¿é²ç®çãšããŠäœ¿çšãããããã«äŒŽãè¬å€èæ§èãåºçŸããŠãããåç©ã§åºçŸããè¬å€èæ§èã¯ç£å»çåéã®æ²»çå¹æãæžåŒ±ãããã»ããçç£ç©çãä»ããŠããã«äŒæããããšãå±æ§ãããŠãããäžçä¿å¥æ©é¢ïŒWHOïŒã¯2011幎ãäžçä¿å¥ããŒã§è¬å€èæ§èã®åé¡ãåãäžããè¬å€èæ§èã®æå¶ãšæžå°ã®ããã«ãããåç©ãšããå£æ ¹ãè¶ ããäžäœçãªåãçµã¿ïŒã¯ã³ãã«ã¹ã»ã¢ãããŒãïŒã®å¿ èŠæ§ã蚎ããããã®èãã¯åœéçã«åãå ¥ããããè¬å€èæ§ã«é¢ããã¯ã³ãã«ã¹ã»ã¢ãããŒãã®åçµã匷åãããŠãããã¡ãã·ãªã³èæ§é»è²ãããŠçèïŒMRSAïŒã¯ããåœã«ãããŠé¢å ææã®äž»èŠãªåå ã§ãããMRSAã¯é»è²ãããŠçèStaphylococcus aureus ãå¯åæ§éºäŒåã«ã»ãã(SCCmec)ã«ããéã°ããmecAéºäŒåãå€éšããç²åŸããããšã§ã¡ãã·ãªã³ã«å¯ŸããŠèæ§ãç²åŸãããMRSA ã¯ãããžã®ç åæ§ãéåžžã«åŒ·ããææããå Žåã«æ»äº¡ããäŸãå€ãããã®ããå»ççŸå Žã§ã¯MRSAã«å¯Ÿããæ§ã ãªå¯ŸçãåãããŠãããã2014幎ã®åçåŽåçã®èª¿æ»ã«ãããšå ¥é¢æ£è ããã®MRSAã®åé¢çã¯49.1%ãšè«žå€åœã«æ¯ã¹éåžžã«é«ããMRSAã®å¶åŸ¡ã¯é¢å ææ察çã®æåªå 課é¡ã®äžã€ã§ãããæµ·å€ã§ã¯å®¶çãé«çïŒ11-46ïŒ ïŒã«MRSAãä¿æããŠããäºå®ãå ±åãããŠããã家çããåé¢ãããMRSAã¯Multi Locus Sequence Typingã§äž»ã«ST398ã«åå¥ãããç£å»çã§å€ã䜿çšãããããã©ãµã€ã¯ãªã³ç³»æèè¬ãžé«åºŠèæ§ã瀺ããªã©ãå»ççŸå Žç±æ¥æ ªãšæ§ç¶ãç°ãªãããšããã家çé¢é£åLivestockassociated(LA-)MRSAããšåä»ããããæ°åã®MRSAãšããŠæ³šç®ããããLA-MRSAã¯ã家çã«ãšã©ãŸããå»ççŸå ŽãžäŸµå ¥ããé¢å ææãèµ·ãããå ±åãããããšããã家çâããéã®MRSAã®äŒæé²æ¢å¯Ÿçã®ããã«ã家ççŸå Žã«ãããMRSAã®ä¿èç¶æ³ã«é¢ãã調æ»ãæµ·å€ã§æŽ»çºã«å®æœãããŠãããããåœã§ãæ¯å¹Žå€ãã®æèè¬ã家çãžäœ¿çšããããã®éã¯å»ççŸå Žã®äœ¿çšéã®ããã2åãšãããã家çç±æ¥è¬å€èæ§èã®åºçŸãžã®æžå¿µããããã®ååã¯èŸ²ææ°Žç£çã®å®¶çç±æ¥çŽ°èã®è¬å€èæ§ã¢ãã¿ãªã³ã°äºæ¥ïŒJVARMïŒã«ããç£èŠãããŠããããããJVARMã«ããã¢ãã¿ãªã³ã°ã¯å€§è žèãã«ã³ãããã¯ã¿ãŒãªã©ã察象èçš®ãšããŠãããMRSAã®ååã¯æããã«ãããŠããªããæ¬ç 究ã§ã¯ãã¯ã³ãã«ã¹ã»ã¢ãããŒãã«åºã¥ããããåœã®å®¶çã«ãããMRSAã®çŸç¶ã®è§£æãšãããžã®äŒæé²æ¢å¯Ÿçãžã®å¿çšãç®çãšããã第1ç« ã§ã¯ã家çã«ãããMRSAã®ååžç¶æ³ãæããã«ãããããåœå ã«ãããçç£å°åã®1ã€ã§ããèšåçã®è±100é ããMRSAãåé¢ãããç¶ããŠç¬¬2ç« ã§ã¯ããã詳现ã«åœå ã«ãããMRSAã®ååžç¶æ³ã調æ»ãããã調æ»å¯Ÿè±¡å®¶çããã³å¯Ÿè±¡å°åãæ¡å€§ããåæµ·éã®çãšè±ã®åèš436é ããMRSAã®åé¢ãè©Šã¿ãããŸãåæã«ãMRSAåæ§ã«SCCmecãä¿æããSCCmecã®ãªã¶ãŒããŒãšãããã¡ãã·ãªã³èæ§ã³ã¢ã°ã©ãŒãŒé°æ§ãããŠçèïŒMRCNSïŒãããã³ã¡ãã·ãªã³æåæ§é»è²ãããŠçèïŒMSSAïŒãåé¢ãæ§ç¶è§£æãå®æœãããæåŸã«ã第3ç« ã§ã¯å®¶çç±æ¥MRSAãšããç±æ¥MRSAãšã®é¢é£ãããã³é£èãMRSAã®äŒæåªäœãšãªãå¯èœæ§ã«ã€ããŠæ€èšããããã家çãé£èãããç±æ¥MRSAã®æ§ç¶ãæ¯èŒããã第1ç« ã«ãããç 究ã®çµæãèšåçã®ãšçå Žæ¬å ¥è±100é äž8é ïŒ8%ïŒããMRSAãåé¢ããããååç«åŠè§£æã®çµæãæµ·å€ã®LA-MRSAã®1ã€ã§ããST97/SCCmec Vãåé¢ãããããã©ãµã€ã¯ãªã³èæ§ããã¯ãã©ã€ãç³»æåæ§ããªã³ã³ãµããç³»èæ§ãšLA-MRSAã«ç¹åŸŽçãªè¬å€æåæ§ãã¿ãŒã³ã瀺ãããæ¥æ¬ã§ã¯å€ãã®å®¶çãèŒžå ¥ããŠãããæµ·å€ããæã¡èŸŒãŸããå¯èœæ§ãèãããããæ¬ç 究ã§ã¯ãæµ·å€ã§æµè¡ããLA-MRSAã«é¡äŒŒããMRSAããããåœã®è±ã«ãååžããããšãåããŠæããã«ããã第2ç« ã§ã¯ãåæµ·éã®ãšçå Žã«æ¬å ¥ãããè±217é ãç219é ããMRSAãMRCNSãããã³MSSAã®åé¢ãè¡ã£ããMRSAã¯è±ããã³çããåé¢ãããªãã£ããã6ïŒ44ïŒ ã®MRCNSãã21ïŒ70ïŒ ã®MSSAãåé¢ããããããã«ãè±ç±æ¥MSSAã¯CC9åã³CC398ãçç±æ¥MSSAã¯CC97ãåªå¢ãªã¿ã€ãã§ãæµ·å€ã®LA-MRSAãšéºäŒååãåãMSSAãååžããŠããããšãæãããšãªã£ããä»ååŸãããçµæãããæ¥æ¬ã®å®¶çã«ãããMRSAã®ä¿èå²åã¯æµ·å€ã«æ¯ã¹äœããã®ã®ãä»åŸæµ·å€ãšåãLA-MRSAãçºçããããããããããšã瀺åãããã第3ç« ã§ã¯ã第1ç« ã§åé¢ãããè±ç±æ¥8æ ªãåäžãåããé£èç±æ¥8æ ªãçä¹³æ¿çç±æ¥7æ ªãããç±æ¥100æ ªã®MRSAã察象ã«ååç«åŠè§£æãå®æœãããã®æ§ç¶ãæ¯èŒãããçµæãçä¹³æ¿çç±æ¥ãé£èç±æ¥ãããç±æ¥åžäžææåMRSAïŒCA-MRSAïŒãéåžžã«è¿çžã§ãã£ãããšãæãããšããããããè¿çžãªMRSAã¯æ¥æ¬ã®åžäžã§è¿å¹Žæ¥æ¿ã«åºãŸã£ãŠããã¿ã€ãã®MRSAïŒCA-MRSA/JïŒã§ãçããã³é£èããã®åé¢å ±åã¯æ¬ç 究ãåããŠãšãªã£ãããããŸã§ã®èª¿æ»ãããæ¥æ¬ã®å®¶çã«ãããMRSAååžç¶æ³ã¯éåžžã«äœããCA-MRSA/Jã®åé¢å ±åã¯ç¡ãããŸããé£èããåé¢ãããMRSAã¯å€ããããç±æ¥ã§ããã³ããªã³ã°ãªã©ã«ããæ±æã§ããããšãçãããŠãããããããèæ¯ãããæ¬ç 究ã«ãããŠé£èç±æ¥MRSAã®æ±ææºãç¹å®ããããšã¯ã§ããªãããããç±æ¥ã§ãã£ãå¯èœæ§ãé«ãããšãèãããããæ¬ç 究ã«ãããŠçâé£èâããéã«ãããŠãäœããã®äŒæçµè·¯ãååšãããããšã瀺åãããã以äžã®æ瞟ãããããåœã®è±ããã³çã®MRSAãMRCNSãããã³MSSAã«é¢ããæ°ããªååç«åŠæ å ±ãæäŸããããšãã§ãããããã«ãçãé£èãããç±æ¥MRSAã«éºäŒåŠçé¢é£ãããããããã®éã§äŒæçµè·¯ãååšããå¯èœæ§ã瀺ãããæ¬ç 究ã«ãããäŒæçµè·¯ãé®æãããšãããæ°ããªè¬å€èæ§è察çãæ§ç¯ããããã®æçšãªç¥èŠãæäŸããããšãã§ãããéå§ããŒãž : 1çµäºããŒãž : 56
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