AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する

• Material Type: 博士論文
• Title: AIDとAID活性化因子であるNF-kB、PAX5の異所性発現は、EBV関連胃癌とは関連しないが、一部のEBV非関連胃癌の発がんに関連する
• Author/Editor: 毛利, 崇; Mori, Takashi
• Author Heading: 毛利, 崇; Mori, Takashi
• Publication Date: 2017-09-30
• Publication Date (W3CDTF): 2017-09-30
• Alternative Title: Aberrant expression of AID and AID activators of NF-kB and PAX5 is irrelevant to EBV-associated gastric cancers, but is associated with carcinogenesis in certain EBV-non-associated gastric cancers
• Degree grantor/type: 鳥取大学
• Date Granted: 2017-09-30
• Date Granted (W3CDTF): 2017-09-30
• Dissertation Number: 甲第859号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第859号
• Text Language Code: eng
• Subject Heading: activation-induced cytidine deaminase; Epstein-Barr virus-associated gastric cancer; nuclear factor κB; paired box 5; c-Myb proto-oncogene
• Target Audience: 一般
• Note (General): Epstein‑Barr virus‑associated gastric carcinoma (EBVaGC) is a distinct subtype of gastric cancer characterized by clinicopathological features including lymphoepithelioma‑like histology. Aberrant expression of activation‑induced cytidine deaminase (AID) as a genomic modulator was demonstrated through pathogen‑related nuclear factor κB (NF‑κB) signaling in Helicobacter pylori‑associated gastric cancer. To elucidate whether or not AID expression is relevant to carcinogenesis in EBVaGC, immunohistochemical expression of AID and AID‑regulatory factors between EBVaGC and EBV‑non‑associated gastric carcinoma (GC) were evaluated, each using 15 cases of GC with lymphoid stroma (GCLS) and other types of GC. Aberrant expression of AID, NF‑κB and paired box 5 (PAX5) were significantly decreased in EBVaGC (0/11, 1/11 and 1/11) compared with in EBV‑non‑associated GC (7/19, 12/19 and 11/19) (P=0.025, 0.005 and 0.01, respectively); however, no significant difference in c‑Myb proto‑oncogene expression was identified. AID expression was also decreased in EBV‑associated GCLS (0/10) compared with in EBV‑non‑associated GCLS (3/5). Unexpectedly, decreased expression of NF‑κB and PAX5 was observed in GCLS (1/15 and 2/15) compared with in GC without LS (12/15 and 10/15) (P<0.001 and P=0.003, respectively). Decreased AID expression observed in EBVaGC is consistent with the reported molecular characterization of hypermethylation and rare somatic gene mutation in EBVaGC. Only PAX5 was identified to be significantly associated with venous invasion (P=0.022). The results of the present study suggest that pathogen‑induced AID expression may be irrelevant to carcinogenesis of EBVaGC, whereas it contributes to carcinogenesis in certain types of EBV‑non‑associated GC.; This research was published by Spandidos Publications: Mohri, T., Nagata, K., Kuwamoto, S., Matsushita, M., Sugihara, H., Kato, M. ... Hayashi, K. (2017). Aberrant expression of AID and AID activators of NF-κB and PAX5 is irrelevant to EBV-associated gast; https://spandidos-publications.com/ol/13/6/4133
• DOI: info:doi/10.3892/ol.2017.5978; https://doi.org/info:doi/10.3892/ol.2017.5978
• Persistent ID (NDL): info:ndljp/pid/11099557; https://dl.ndl.go.jp/pid/11099557
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-06-04T01:14:06+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://repository.lib.tottori-u.ac.jp/records/5843
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp