Degradation rate of DNA scaffolds and bone regeneration.

• Material Type: 博士論文
• Title: Degradation rate of DNA scaffolds and bone regeneration.
• Author/Editor: Matsumoto, Ayako; Kajiya, Hiroshi; Yamamoto-M, Nana; Yanagi, Tsukasa; Imamura, Ayaka; Okabe, Koji; Fukushima, Tadao; Kido, Hirofumi; Ohno, Jun
• Author Heading: Matsumoto, Ayako; Kajiya, Hiroshi; Yamamoto-M, Nana; Yanagi, Tsukasa; Imamura, Ayaka; Okabe, Koji; Fukushima, Tadao; Kido, Hirofumi; Ohno, Jun
• Publication Date: 2018-03-29
• Publication Date (W3CDTF): 2018-03-29
• Alternative Title: Degradation rate of DNA scaffolds and bone regeneration.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2018-03-29
• Date Granted (W3CDTF): 2018-03-29
• Dissertation Number: 甲第296号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第296号
• Text Language Code: eng
• Subject Heading: biodegradation; bone regeneration; calvarial defect; phosphate; scaffold
• Target Audience: 一般
• Note (General): Scaffolds implanted into bone defect sites must achieve optimal biodegradation rates while appropriately filling the void as new bone formation progresses. We recently developed a unique biomaterial consisting of salmon deoxyribose nucleic acid (DNA) and protamine, which can be used as an osteoconductive scaffold for tissue engineering. The aim of the present study was to elucidate how the degradation rate of the scaffold affects bone regeneration. We examined the relationships between the degradation rate of salmon DNA scaffolds and new bone formation using a rat skin flank subcutaneous model and rat calvarial defect model. The degradation rates of the scaffolds were proportional to the durations of pretreatment with ultraviolet (UV) light irradiation. The biodegradation rates of the scaffolds were also dependent on the duration of UV irradiation, as tested a subcutaneous tissue implantation. Scaffolds irradiated with UV light for 0.5 h maintained gradual biodegradation of phosphate compared with scaffolds irradiated for 0 or 3 h. In the calvarial defect model, we found that new bone formation was higher in rats treated with scaffolds irradiated with UV light for 0.5 h compared with those irradiated with UV light for 0 or 3.0 h. The present results suggest that bioengineering of scaffolds for biodegradation is important to regenerate bone. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018.
• Persistent ID (NDL): info:ndljp/pid/11099561; https://dl.ndl.go.jp/pid/11099561
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-06-04T01:14:06+09:00
• Date Created (W3CDTF): 2018-05-24
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/84
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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