Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation 80 10

The cover of this title could differ from library to library.

Available in National Diet Library

Find on the publisher's website

国立国会図書館デジタルコレクション

Digital data available

Check on the publisher's website

DOI[info:doi/10.1080/09168451.2016.1191334]to the data of the same series

Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation 10

Persistent ID (NDL): info:ndljp/pid/11099681

Material type: 博士論文

Author: Nuka, Erikaほか

Publisher: Taylor & Francis|Japan Society for Bioscience, Biotechnology, and Agrochemistry

Publication date: 2016-06-07

Material Format: Digital

Capacity, size, etc.: -

Name of awarding university/degree: 徳島大学,博士（栄養学）

View All

Notes on use at the National Diet Library

本資料は、掲載誌(URI)等のリンク先にある学位授与機関のWebサイトやCiNii Dissertationsから、本文を自由に閲覧できる場合があります。

Notes on use

Note (General)：: Lipid peroxidation products react with cellular molecules, such as DNA bases, to form covalent adducts, which are associated with aging and disease pr...

Search by Bookstore

Read this material in an accessible format.

View materials in accessible formats for people with print disabilities (1Type)

Search by Bookstore

Read in Disability Resources

Other Services
- テキストデータ check it on 国立国会図書館デジタルコレクション

Bibliographic Record

You can check the details of this material, its authority (keywords that refer to materials on the same subject, author's name, etc.), etc.

Digital

Material Type: 博士論文
ISSN: 0916-8451
Title: Metal-catalyzed oxidation of 2-alkenals generates genotoxic 4-oxo-2-alkenals during lipid peroxidation
Volume: 80 10
Author/Editor: Nuka, Erika
Tomono, Susumu
Ishisaka, Akari
Kato, Yoji
Miyoshi, Noriyuki
Kawai, Yoshichika
Author Heading: Nuka, Erika
Tomono, Susumu
Ishisaka, Akari
Kato, Yoji
Miyoshi, Noriyuki
Kawai, Yoshichika
Publication, Distribution, etc.: Taylor & Francis|Japan Society for Bioscience, Biotechnology, and Agrochemistry
Publication Date: 2016-06-07
Publication Date (W3CDTF): 2016-06-07
Alternative Title: 脂質過酸化反応において金属触媒による2-アルケナールの酸化は、遺伝毒性を有する4-オキソ-2-アルケナールを生成する
Metal-catalyzed formation of 4-oxo-2-alkenals
Periodical title: Bioscience, Biotechnology, and Biochemistry
Degree grantor/type: 徳島大学
Date Granted: 2018-03-23
Date Granted (W3CDTF): 2018-03-23
Dissertation Number: 甲第3147号
Degree Type: 博士（栄養学）
Conferring No. (Dissertation): 甲第3147号
Text Language Code: eng
Subject Heading: Lipid peroxidation
DNA adducts
LC-MS/MS
4-oxo-2-alkenals
transition metals
Target Audience: 一般
Note (General): Lipid peroxidation products react with cellular molecules, such as DNA bases, to form covalent adducts, which are associated with aging and disease processes. Since lipid peroxidation is a complex process and occurs in multiple stages, there might be yet unknown reaction pathways. Here, we analyzed comprehensively 2’-deoxyguanosine (dG) adducts with oxidized arachidonic acid using liquid chromatography-tandem mass spectrometry and found the formation of 7-(2-oxo-hexyl)-etheno-dG as one of the major unidentified adducts. The formation of this adduct was reproduced in the reaction of dG with 2-octenal and predominantly with 4-oxo-2-octenal (OOE). We also found that other 2-alkenals (with five or more carbons) generate corresponding 4-oxo-2-alkenal-type adducts. Importantly, it was found that transition metals enhanced the oxidation of C4-position of 2-octenal, leading to the formation of OOE-dG adduct. These findings demonstrated a new pathway for the formation of 4-oxo-2-alkenals during lipid peroxidation and might provide a mechanism for metal-catalyzed genotoxicity.
DOI: info:doi/10.1080/09168451.2016.1191334
https://doi.org/info:doi/10.1080/09168451.2016.1191334
Persistent ID (NDL): info:ndljp/pid/11099681
https://dl.ndl.go.jp/pid/11099681
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-06-04T01:14:06+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111621
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp