High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer

• Material Type: 博士論文
• Title: High ubiquitin-specific protease 44 expression induces DNA aneuploidy and provides independent prognostic information in gastric cancer
• Author/Editor: 西村, 章
• Author Heading: 西村, 章
• Publication Date: 2017-12-31
• Publication Date (W3CDTF): 2017-12-31
• Alternative Title: USP44高発現は細胞のDNA aneuploidy を誘導し、胃癌の独立予後不良因子となる。
• Contributor: 加藤, 聖子; 中村, 雅史; 康, 東天
• Degree grantor/type: 九州大学
• Date Granted: 2017-12-31
• Date Granted (W3CDTF): 2017-12-31
• Dissertation Number: 甲第13801号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13801号
• Text Language Code: jpn
• Target Audience: 一般
• Note (General): Chromosomal instability (CIN), characterized by aneuploidy, is a major molecular subtype of gastric cancer. The deubiquitinase USP44 is an important regulator of APC activation in the spindle checkpoint and leads to proper chromosome separation to prevent aneuploidy. Aberrant expression of USP44 leads CIN in cells; however, the correlation between USP44 and DNA aneuploidy in gastric cancer is largely unknown. We analyzed USP44 expression in 207 patients with gastric cancer by immunohistochemistry and found that the proportion of USP44 expression was higher in gastric cancer tumors (mean, 39.6%) than in gastric normal mucosa (mean, 14.6%) (P < 0.0001). DNA aneuploidy was observed in 124 gastric cancer cases and high USP44 expression in cancer strongly correlated with DNA aneuploidy (P = 0.0005). The overall survival was significantly poorer in the high USP44 expression group compared with the low USP44 group (P = 0.033). Notably, USP44 expression had no prognostic impact in the diploid subgroup; however, high USP44 expression was a strong poor prognostic factor for progression-free survival (P = 0.018) and overall survival (P = 0.036) in the aneuploid subgroup. We also confirmed that stable overexpression of USP44 induced somatic copy-number aberrations in hTERT-RPE-1 cells (50.6%) in comparison with controls (6.6%) (P < 0.0001). Collectively, our data show USP44 has clinical impact on the induction of DNA aneuploidy and poor prognosis in the CIN gastric cancer subtype.; PubMed番号 : 28544703
• DOI: 10.15017/1928625; https://doi.org/10.15017/1928625
• Persistent ID (NDL): info:ndljp/pid/11116032; https://dl.ndl.go.jp/pid/11116032
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-07-03T21:49:10+09:00
• Date Created (W3CDTF): 2018-05-09
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1928625; http://hdl.handle.net/2324/1928625
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2018-10-04 再収集

2018-10-04 再収集

2018-10-04 再収集

2023-09-01 再収集

2023-09-01 再収集