p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock

• Material Type: 博士論文
• Title: p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock
• Author/Editor: 佐々木, 勝彦
• Author Heading: 佐々木, 勝彦
• Publication Date: 2018-02-28
• Publication Date (W3CDTF): 2018-02-28
• Alternative Title: ｐ32はＬＰＳ刺激によるインターロイキン6の量を調節し敗血症性ショックからマウスを守る
• Contributor: 大賀, 正一; 林, 哲也; 新納, 宏昭
• Degree grantor/type: 九州大学
• Date Granted: 2018-02-28
• Date Granted (W3CDTF): 2018-02-28
• Dissertation Number: 甲第13911号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13911号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Sepsis is a major cause of morbidity and mortality in seriously ill patients and mitochondrial dysfunction is associated with poor outcomes in septic patients. Although interleukin-6 (IL-6) is a good prognostic marker for sepsis, the relationship between mitochondrial dysfunction and IL-6 remains poorly understood. We identified p32/C1QBP/HABP1 as a regulator of IL-6 production in response to lipopolysaccharide (LPS). LPS induced IL-6 overproduction in p32 deficient mouse embryonic fibroblasts (MEFs) through NF-κB independent but activating transcription factor (ATF) 4 dependent pathways. Short hairpin RNA-based knockdown of ATF4 in p32 deficient MEFs markedly inhibited LPS-induced IL-6 production. Furthermore, MEFs treated with chloramphenicol, an inhibitor of mitochondrial translation, produced excessive IL-6 via ATF4 pathways. Using a LPS-induced endotoxin shock model, mice with p32 ablation in myeloid cells showed increased lethality and overproduction of IL-6. Thus, this study provides a molecular link how mitochondrial dysfunction leads to IL-6 overproduction and poor prognosis of sepsis.; PubMed番号 : 28549777
• DOI: 10.15017/1931764; https://doi.org/10.15017/1931764
• Persistent ID (NDL): info:ndljp/pid/11116167; https://dl.ndl.go.jp/pid/11116167
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-07-03T21:49:10+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931764; http://hdl.handle.net/2324/1931764
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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