Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan

• Material Type: 博士論文
• Title: Epidemiologic Research on Malformations Associated with Cleft Lip and Cleft Palate in Japan
• Author/Editor: 古賀, 寛史
• Author Heading: 古賀, 寛史
• Publication Date: 2018-02-28
• Publication Date (W3CDTF): 2018-02-28
• Alternative Title: 日本国内における口唇裂口蓋裂患者の合併奇形に関する疫学調査
• Contributor: 田口, 智章; 加藤, 聖子; 二宮, 利治
• Degree grantor/type: 九州大学
• Date Granted: 2018-02-28
• Date Granted (W3CDTF): 2018-02-28
• Dissertation Number: 乙第08712号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第08712号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-NICU facilities and to determine whether there are differences among facilities. The regional survey investigated NICU facilities located in Oita Prefecture, including 92 patients with cleft lip and palate (CLP) or cleft palate (CP) that occurred between 2004 and 2013, and the national survey investigated oral surgery, plastic surgery, and obstetrics and gynecology facilities located in Japan, including 16,452 patients with cleft lip (CL), CLP, or CP that occurred since 2000. The incidence per 10,000 births was 4.2, 6.2, and 2.8 for CL, CLP, and CP, respectively, according to the national survey, and 6.3 and 2.9 for CLP and CP, respectively according to the regional survey. These results indicated comparable incidences between the two surveys. In contrast, when the survey results on malformations associated with CLP and CP according to the ICD-10 classification were compared between the national survey conducted at oral surgery or plastic surgery facilities and the regional survey conducted at NICU facilities, the occurrence of associated malformations was 19.8% vs. 41.3% for any types of associated malformation, 6.8% vs. 21.7% for congenital heart disease, and 0.5% vs. 16.3% for chromosomal abnormalities. These results indicated that the incidences of all of these associated malformations were significantly greater in the survey conducted at NICU facilities and similar to the findings from international epidemiological surveys. When comparing the survey conducted at obstetrics facilities vs. NICU facilities, the occurrence of associated malformations was similar results as above. The incidence of CLP and CP was not different between surveys conducted at NICU facilities vs. non-NICU facilities; however, when conducting surveys on associated malformations, it is possible to obtain accurate epidemiological data by investigating NICU facilities where detailed examinations are thoroughly performed.; PubMed番号 : 26901758
• DOI: 10.15017/1931999; https://doi.org/10.15017/1931999
• Persistent ID (NDL): info:ndljp/pid/11116176; https://dl.ndl.go.jp/pid/11116176
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-07-03T21:49:10+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931999; http://hdl.handle.net/2324/1931999
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: To investigate malformations associated with cleft lip and cleft palate, we conducted surveys at neonatal intensive care units (NICUs) and other non-N...

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