Bone induction by α-tricalcium phosphate microparticle emulsion containing simvastatin

Persistent ID (NDL): info:ndljp/pid/11116776

Material type: 博士論文

Author: 舘山, 彰人

Publisher: Hokkaido University

Publication date: 2018-03-22

Material Format: Digital

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Name of awarding university/degree: 北海道大学,博士(歯学)

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Note (General)：: To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate ...

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Material Type: 博士論文
Title: Bone induction by α-tricalcium phosphate microparticle emulsion containing simvastatin
Author/Editor: 舘山, 彰人
Author Heading: 舘山, 彰人
Publication, Distribution, etc.: Hokkaido University
Publication Date: 2018-03-22
Publication Date (W3CDTF): 2018-03-22
Alternative Title: シンバスタチン添加α-リン酸三カルシウム微粒子エマルションの骨形成効果
Contributor: 網塚, 憲生
菅谷, 勉
土門, 卓文
Degree grantor/type: 北海道大学
Date Granted: 2018-03-22
Date Granted (W3CDTF): 2018-03-22
Dissertation Number: 甲第13048号
Degree Type: 博士(歯学)
Conferring No. (Dissertation): 甲第13048号
Text Language Code: eng
Subject Heading: α-tricalcium phosphate (TCP)
bone tissue engineering
bone paste
water-oil emulsion
rat
simvastatin
NDC: 497
Target Audience: 一般
Note (General): To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects. Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.
(主査) 教授網塚憲生, 准教授菅谷勉, 教授土門卓文
歯学研究科（口腔医学専攻）
DOI: 10.14943/doctoral.k13048
https://doi.org/10.14943/doctoral.k13048
Persistent ID (NDL): info:ndljp/pid/11116776
https://dl.ndl.go.jp/pid/11116776
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-07-03T21:49:10+09:00
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k13048
http://hdl.handle.net/2115/70749
Is Referenced By (URI): http://hdl.handle.net/2115/70748
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp