Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging

• Material Type: 博士論文
• ISSN: 1549-9634
• Title: Intratumoral evaluation of 3D microvasculature and nanoparticle distribution using a gadolinium-dendron modified nano-liposomal contrast agent with magnetic resonance micro-imaging
• Volume: 14 4
• Author/Editor: Nitta, Nobuhiro; Takakusagi, Yoichi; Kokuryo, Daisuke; Shibata, Sayaka; Tomita, Akihiro; Higashi, Tatsuya; Aoki, Ichio; Harada, Masafumi
• Author Heading: Nitta, Nobuhiro; Takakusagi, Yoichi; Kokuryo, Daisuke; Shibata, Sayaka; Tomita, Akihiro; Higashi, Tatsuya; Aoki, Ichio; Harada, Masafumi
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018-04-04
• Publication Date (W3CDTF): 2018-04-04
• Alternative Title: MRマイクロイメージングとガドリニウム-デンドロン修飾ナノリポソーム造影剤を用いた3D微小血管およびナノ粒子分布の腫瘍内評価
• Periodical title: Nanomedicine : Nanotechnology, Biology and Medicine
• Degree grantor/type: 徳島大学
• Date Granted: 2018-05-24
• Date Granted (W3CDTF): 2018-05-24
• Dissertation Number: 甲第3200号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3200号
• Text Language Code: eng
• Subject Heading: liposomal contrast agent; tumor heterogeneity; angiography; MRI; EPR
• Target Audience: 一般
• Note (General): The enhanced permeability and retention (EPR) effect is variable depending on nanoparticle properties and tumor/vessel conditions. Thus, intratumoral evaluations of the vasculature and nanoparticle distribution are important for predicting the therapeutic efficacy and the intractability of tumors. We aimed to develop a tumor vasculature evaluation method and high-resolution nanoparticle delivery imaging using magnetic resonance (MR) micro-imaging technology with a gadolinium (Gd)-dendron assembled liposomal contrast agent. Using the Gd-liposome and a cryogenic receiving coil, we achieved 50-μm isotropic MR angiography with clear visualization of tumor micro-vessel structure. The Gd-liposome-enhanced MR micro-imaging revealed differences in the vascular structures between Colon26- and SU-DHL6-grafted mice models. The vessel volumes and diameters measured for both tumors were significantly correlated with histological observations. The MR micro-imaging methods facilitate the evaluation of intratumoral vascularization patterns, the quantitative assessment of vascular-properties that alter tumor malignancy, particle retentivity, and the effects of treatment.
• DOI: info:doi/10.1016/j.nano.2018.03.006; https://doi.org/info:doi/10.1016/j.nano.2018.03.006
• Persistent ID (NDL): info:ndljp/pid/11116843; https://dl.ndl.go.jp/pid/11116843
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-07-03T21:49:10+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111810
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp