Angiotensin receptor blocker telmisartan inhibits cell proliferation and tumor growth of cholangiocarcinoma through cell cycle arrest

Persistent ID (NDL): info:ndljp/pid/11122660

Material type: 博士論文

Author: 寒川, 英里

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Publication date: 2018-03-24

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractCholangiocarcinoma (CCA) is at an advanced stage at the time of its diagnosis, and developing a more effective treatment of CCA would be desir...

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Material Type: 博士論文
Title: Angiotensin receptor blocker telmisartan inhibits cell proliferation and tumor growth of cholangiocarcinoma through cell cycle arrest
Author/Editor: 寒川, 英里
Author Heading: 寒川, 英里
Publication Date: 2018-03-24
Publication Date (W3CDTF): 2018-03-24
Degree grantor/type: 香川大学
Date Granted: 2018-03-24
Date Granted (W3CDTF): 2018-03-24
Dissertation Number: 甲第680号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第680号
Text Language Code: eng
Alias of Author: Samukawa, Eri
Subject Heading: cholangiocarcinoma
telmisartan
cell cycle
angiotensin II type 1 receptor blocker
Target Audience: 一般
Note (General): AbstractCholangiocarcinoma (CCA) is at an advanced stage at the time of its diagnosis, and developing a more effective treatment of CCA would be desirable. Angiotensin II type 1 (AT1) receptor blocker (ARB), telmisartan may inhibit cancer cell proliferation, but the mechanisms by which telmisartan affects various cancers remain unknown. In this study, we evaluated the effects of telmisartan on human CCA cells and to assess the expression of microRNAs (miRNAs). We studied the effects of telmisartan on CCA cells using two cell lines, HuCCT-1 and TFK-1. In our experiments, telmisartan inhibited the proliferation of HuCCT-1 and TFK-1 cells. Additionally, telmisartan induced G0/G1 cell cycle arrest via blockade of the G0 to G1 cell cycle transition. Notably, telmisartan did not induce apoptosis in HuCCT-1 cells. This blockade was accompanied by a strong decrease in cell cycle-related protein, especially G1 cyclin, cyclin D1, and its catalytic subumits, Cdk4 and Cdk6. Telmisartan reduced the phosphorylation of EGFR (p-EGFR) and TIMP-1 by using p-RTK and angiogenesis array. Furthermore, miRNA expression was markedly altered by telmisartan in HuCCT-1. Telmisartan inhibits tumor growth in CCA xenograft model in vivo. In conclusion, telmisartan was shown to inhibit human CCA cell proliferation by inducing cell cycle arrest.
DOI: info:doi/10.3892/ijo.2017.4177
https://doi.org/info:doi/10.3892/ijo.2017.4177
Persistent ID (NDL): info:ndljp/pid/11122660
https://dl.ndl.go.jp/pid/11122660
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/301
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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