The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy Residents of Japan:Results from the Kyushu and Okinawa Population Study(KOPS)

• Material Type: 博士論文
• Title: The Relation between Serum Endostatin Level and Carotid Atherosclerosis in Healthy Residents of Japan:Results from the Kyushu and Okinawa Population Study(KOPS)
• Author/Editor: 加藤, 禎史
• Author Heading: 加藤, 禎史
• Publication Date: 2018-03-20
• Publication Date (W3CDTF): 2018-03-20
• Alternative Title: 一般住民健常者における血清エンドスタチン値と頚動脈硬化の関連 Kyushu Okinawa Population Study (KOPS)より
• Contributor: 二宮, 利治; 北園, 孝成; 馬場園, 明
• Degree grantor/type: 九州大学
• Date Granted: 2018-03-20
• Date Granted (W3CDTF): 2018-03-20
• Dissertation Number: 甲第13926号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13926号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): AIM:To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a healthy Japanese population. / METHODS:Among 1,057 residents who attended free public physical examinations between 2010 and 2011, we evaluated the data of 648 healthy residents for whom the serum endostatin level and common carotid intima-media thickness (IMT) were successfully measured. / RESULTS:The median endostatin level was 63.7 ng/mL (interquartile ranges: 49.7-93.2 ng/mL), and the mean carotid IMT was 0.68±0.12 mm. Residents with above median endostatin had significantly higher carotid IMT than did those with below median endostatin (0.71±0.14 vs. 0.65±0.09 mm, P＜0.001). Multiple linear regression analysis demonstrated that increased serum endostatin is significantly associated with carotid IMT (above vs. below median endostatin level; beta=0.11, P=0.03), independent of the known covariates of age, sex, body mass index, drinking and smoking status, systolic blood pressure, diastolic blood pressure, hemoglobin A1c, low density lipoprotein cholesterol, estimated glomerular filtration rate, and log-transformed high sensitive C-reactive protein. / CONCLUSIONS:A higher serum endostatin level reflected subclinical atherosclerosis in this Japanese population.; PubMed番号 : 28428451
• DOI: 10.15017/1931779; https://doi.org/10.15017/1931779
• Persistent ID (NDL): info:ndljp/pid/11122671; https://dl.ndl.go.jp/pid/11122671
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931779; http://hdl.handle.net/2324/1931779
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: AIM:To examine the association between the serum endostatin levels and subclinical atherosclerosis independent of traditional risk factors in a health...

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