Correlation between Thyroid Stimulating Hormone and Renal Function in Euthyroid Residents of Japan:Results from the Kyushu and Okinawa Population Study(KOPS)

• Material Type: 博士論文
• Title: Correlation between Thyroid Stimulating Hormone and Renal Function in Euthyroid Residents of Japan:Results from the Kyushu and Okinawa Population Study(KOPS)
• Author/Editor: 田中, 佑樹
• Author Heading: 田中, 佑樹
• Publication Date: 2018-03-20
• Publication Date (W3CDTF): 2018-03-20
• Alternative Title: 一般住民における甲状腺機能正常範囲内の血清甲状腺刺激ホルモンと腎機能との関連 Kyushu Okinawa Population Study(KOPS)研究より
• Contributor: 鴨打, 正浩; 萩原, 明人; 江藤, 正俊
• Degree grantor/type: 九州大学
• Date Granted: 2018-03-20
• Date Granted (W3CDTF): 2018-03-20
• Dissertation Number: 甲第13929号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13929号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): AIM:The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level and renal function. / METHODS:Out of 1,374 residents who participated in a free public physical examination between 2010 and 2011, we evaluated the data of 888 participants for whom the serum TSH level and estimated glomerular filtration rate (eGFR) were successfully measured. The participants were categorized into three groups based on TSH levels (normal TSH, ≤2.4; high-normal TSH, 2.5-4.4; and subclinical hypothyroid, ≥4.5 μIU/mL). Multiple linear regression analysis adjusted for cardiovascular risk factors was performed to determine the relationship between serum TSH level and renal function. / RESULTS:The mean±SD TSH level was 2.0±1.4 μIU/mL, and 75.9% (n=674) of the participants had normal, 17.9% (n=159) had high-normal, and 6.2% (n=55) had subclinical hypothyroid TSH levels. The mean eGFR significantly decreased with increased TSH levels (normal TSH, 79.3±14.1; high-normal TSH, 77.4±13.0; and subclinical hypothyroid, 72.3±12.2 mL/min/1.73 m2: P for trend ＜0.01). Multiple linear regression analysis extracted log-transformed TSH level as an independent factor correlated with eGFR in the high-normal TSH group (beta=-0.18, P=0.02).; PubMed番号 : 29046502
• DOI: 10.15017/1931782; https://doi.org/10.15017/1931782
• Persistent ID (NDL): info:ndljp/pid/11122673; https://dl.ndl.go.jp/pid/11122673
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931782; http://hdl.handle.net/2324/1931782
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: AIM:The present large-scale Japanese population study was performed to evaluate the relation between the serum thyroid stimulating hormone (TSH) level...

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