Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion

• Material Type: 博士論文
• Title: Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion
• Author/Editor: 河野, 真一
• Author Heading: 河野, 真一
• Publication Date: 2018-03-31
• Publication Date (W3CDTF): 2018-03-31
• Alternative Title: オートファジーは細胞内に取り込まれたコラーゲンの分解を促進し焦点接着の分布を制御して細胞接着を抑制する
• Contributor: 三浦, 岳; 鈴木, 淳史; 中島, 康晴
• Degree grantor/type: 九州大学
• Date Granted: 2018-03-31
• Date Granted (W3CDTF): 2018-03-31
• Dissertation Number: 甲第13957号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13957号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Adhesion of cells to the extracellular matrix (ECM) via focal adhesions (FAs) is crucial for cell survival, migration, and differentiation. Although the regulation of FAs, including by integrins and the ECM, is important to cell behavior, how FAs are regulated is not well known. Autophagy is induced by both cell adhesion and cell detachment. Here, we showed that autophagosomes are located close to internalized collagen and paxillin, which is a well-known marker of FAs. Autophagy-deficient cells showed increased levels of internalized collagen compared with control cells. Moreover, paxillin exhibited a more peripheral distribution and the area of paxillin was increased, and adhesion-induced focal adhesion kinase signaling was impaired and adhesion was enhanced, in autophagy-deficient cells. These results suggest that autophagy suppressed cell adhesion by regulating internalized ECM and FAs.; PubMed番号 : 28970230
• DOI: 10.15017/1931810; https://doi.org/10.15017/1931810
• Persistent ID (NDL): info:ndljp/pid/11122686; https://dl.ndl.go.jp/pid/11122686
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931810; http://hdl.handle.net/2324/1931810
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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