KIT (CD117) expression in benign and malignant sweat gland tumors

• Material Type: 博士論文
• Title: KIT (CD117) expression in benign and malignant sweat gland tumors
• Author/Editor: 西田, 陽登
• Author Heading: 西田, 陽登
• Publication, Distribution, etc.: 大分大学
• Publication Date: 2015
• Publication Date (W3CDTF): 2015
• Alternative Title: 良性および悪性の汗腺系腫瘍におけるKIT (CD117)の発現
• Degree grantor/type: 大分大学
• Date Granted: 2015-03-25
• Date Granted (W3CDTF): 2015-03-25
• Dissertation Number: 甲第534号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲第534号
• Text Language Code: eng
• Subject Heading: sweat gland tumor; KIT (CD117); immunohistochemistry; mutation; tumorigenesis
• Target Audience: 一般
• Note (General): type:Thesis or Dissertation; KIT (CD117, c-kit) is a receptor tyrosine kinase involved in the tumorigenesis of several neoplasms. KIT is expressed by the secretory cells of normal sweat glands. We studied the KIT expression and KIT mutational status in various benign and malignant tumors of eccrine and apocrine glands. We included a total of 108 cases comprising 10 benign and 6 malignant sweat gland tumors, and KIT expression was immunohistochemically detected ( positive rate): 10 syringomas (0%), 8 poromas (25%), 20 mixed tumors (40%), 21 spiradenomas (43%), 1 cylindroma (0%), 5 hidradenomas (40%), 7 syringocystadenoma papilliferum cases (0%), 1 papillary hidradenoma (100%), 2 tubulopapillary hidradenomas (50%), 8 hidrocystomas (29%), 2 adenoid cystic carcinomas (100%), 5 porocarcinomas (20%), 6 apocrine carcinomas (33%), 10 extramammary Paget's disease cases (30%), 1 spiradenocarcinoma (100%), and 1 syringocystadenocarcinoma papilliferum (0%). Most KIT-positive cells were luminal cells, arising from glandular structures. We performed polymerase chain reaction-single-strand conformation polymorphism for detecting KIT mutational status. All cases showed no mutations at hot spots for KIT (exons 9, 11, 13, and 17). KIT mutation does not seem to be mechanism for KIT expression, but the expression may be from native sweat glands.
• Persistent ID (NDL): info:ndljp/pid/11123596; https://dl.ndl.go.jp/pid/11123596
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-07-11
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10559/16423
• Is Version Of (URI): http://dx.doi.org/10.1097/DAD.0000000000000301
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-09-08 再収集