Impairment of the missing fundamental phenomenon in individuals with Alzheimer's disease: a neuropsychological and voxel-based morphometric study

• Material Type: 博士論文
• Title: Impairment of the missing fundamental phenomenon in individuals with Alzheimer's disease: a neuropsychological and voxel-based morphometric study
• Author/Editor: Abe, Makiko
• Author Heading: Abe, Makiko
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2018-03-26
• Publication Date (W3CDTF): 2018-03-26
• Alternative Title: アルツハイマー型認知症患者におけるミッシングファンダメンタル現象の障害：神経心理検査と脳形態計測による検討
• Degree grantor/type: 三重大学
• Date Granted: 2018-03-26
• Date Granted (W3CDTF): 2018-03-26
• Dissertation Number: 甲医学第1877号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1877号
• Text Language Code: eng
• Alias of Author: アベ, マキコ; 阿部, 真貴子; 田部井, 真貴子
• Subject Heading: Alzheimer’s disease; Dementia; Pitch perception; Missing fundamental phenomenon; Magnetic
• Target Audience: 一般
• Note (General): application/pdf; Background/Aims: The missing fundamental phenomenon (MFP) is a universal pitch perception illusion that occurs in animals and humans. In this study, we aimed to determine whether the MFP is impaired in patients with Alzheimer’s disease (AD) using an auditory pitch perception experiment. We further examined anatomical correlates of the MFP in patients with AD by measuring gray matter volume (GMV) on magnetic resonance images via voxel-based morphometric analysis. Methods: We prospectively enrolled 29 patients with AD and 20 healthy older adults. Auditory stimuli included 12 melodies of Japanese nursery songs that were expected to be familiar to participants. We constructed the melodies using pure and missing fundamental tones (MFTs). Results: Patients with AD exhibited significantly poorer performance on the MFT task than healthy controls. MFT scores were positively correlated with GMV in the bilateral insula and temporal poles, left inferior frontal gyrus, right entorhinal cortex, and right cerebellum. Conclusions: These results suggest that impairments in the MFP represent a manifestation of the degeneration of auditory-related brain regions in AD. Further studies are required to more fully elucidate the neural mechanisms underlying auditory impairments in patients with AD and related dementia disorders.; 本文 / Department of Dementia Prevention and Therapeutics, Graduate School of Medicine,Mie University,Mie,Japan; 31p
• DOI: info:doi/10.1159/000486331; https://doi.org/info:doi/10.1159/000486331
• Persistent ID (NDL): info:ndljp/pid/11123700; https://dl.ndl.go.jp/pid/11123700
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-07-17
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017680; https://mie-u.repo.nii.ac.jp/records/12047
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集