MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer

• Material Type: 博士論文
• Title: MicroRNA-7 Is Associated with Malignant Potential and Poor Prognosis in Human Colorectal Cancer
• Author/Editor: Nagano, Yuka
• Author Heading: Nagano, Yuka
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2018-03-26
• Publication Date (W3CDTF): 2018-03-26
• Alternative Title: 大腸癌患者においてmicroRNA-7は悪性診断能および予後予良に関連する
• Degree grantor/type: 三重大学
• Date Granted: 2018-03-26
• Date Granted (W3CDTF): 2018-03-26
• Dissertation Number: 甲医学第1881号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1881号
• Text Language Code: eng
• Alias of Author: ナガノ, ユカ; 長野, 由佳
• Subject Heading: colorectal cancer; miR-7; poor prognosis
• Target Audience: 一般
• Note (General): application/pdf; Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly up-regulated in CRC tissues compared to normal colorectal mucosae. Elevated miR-7 expression was significantly correlated with tumour depth, venous invasion, lymphatic invasion, lymph node metastasis, and liver metastasis. High miR-7 expression was significantly associated with poor overall survival in patients with CRC (p=0.010). Moreover, miR-7 expression was an independent prognostic factor in patients with CRC (hazard ratio=1.854, 95% confidence interval=1.016-3.540; p=0.044). miR-7 acts as an oncogene in CRC and is significantly associated with tumour progression and poor prognosis.; 本文 / Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan; 6p
• DOI: info:doi/10.21873/anticanres.11253; https://doi.org/info:doi/10.21873/anticanres.11253
• Persistent ID (NDL): info:ndljp/pid/11123705; https://dl.ndl.go.jp/pid/11123705
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-07-18
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017689; https://mie-u.repo.nii.ac.jp/records/12056
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集