β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells

• Material Type: 博士論文
• Title: β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells
• Author/Editor: Kainuma, Keigo
• Author Heading: Kainuma, Keigo
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2018-03-26
• Publication Date (W3CDTF): 2018-03-26
• Alternative Title: 気道上皮細胞の好酸球誘導による上皮間葉転換におけるベータ2作動薬による抑制効果
• Degree grantor/type: 三重大学
• Date Granted: 2018-03-26
• Date Granted (W3CDTF): 2018-03-26
• Dissertation Number: 甲医学第1891号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1891号
• Text Language Code: eng
• Alias of Author: カイヌマ, ケイゴ; 貝沼, 圭吾
• Subject Heading: Asthma; Eosinophils; Epithelial cells; Integrins
• Target Audience: 一般
• Note (General): application/pdf; Background: Epithelial-mesenchymal transition is currently recognized as an important mechanism for the increased number of myofibroblasts in cancer and fibrotic diseases. We have already reported that epithelial-mesenchymal transition is involved in airway remodeling induced by eosinophils. Procaterol is a selective and full β2 adrenergic agonist that is used as a rescue of asthmatic attack inhaler form and orally as a controller. In this study, we evaluated whether procaterol can suppress epithelial-mesenchymal transition of airway epithelial cells induced by eosinophils.Methods: Epithelial-mesenchymal transition was assessed using a co-culture system of human bronchial epithelial cells and primary human eosinophils or an eosinophilic leukemia cell line.Results: Procaterol significantly inhibited co-culture associated morphological changes of bronchial epithelial cells, decreased the expression of vimentin, and increased the expression of E-cadherin compared to control. Butoxamine, a specific β2-adrenergic antagonist, significantly blocked changes induced by procaterol. In addition, procaterol inhibited the expression of adhesion molecules induced during the interaction between eosinophils and bronchial epithelial cells, suggesting the involvement of adhesion molecules in the process of epithelial-mesenchymal transition. Forskolin, a cyclic adenosine monophosphate-promoting agent, exhibits similar inhibitory activity of procaterol.Conclusions: Overall, these observations support the beneficial effect of procaterol on airway remodeling frequently associated with chronic obstructive pulmonary diseases.; 本文 / Allergy Center, Mie National Hospital. Department of Immunology, Mie University Graduate School of Medicine; 11p
• DOI: info:doi/10.1186/s12931-017-0563-4; https://doi.org/info:doi/10.1186/s12931-017-0563-4
• Persistent ID (NDL): info:ndljp/pid/11123713; https://dl.ndl.go.jp/pid/11123713
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-07-20
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017709; https://mie-u.repo.nii.ac.jp/records/12077
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集