Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study

• Material Type: 博士論文
• Title: Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study
• Author/Editor: Matsushita, Futoshi
• Author Heading: Matsushita, Futoshi
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2018-03-26
• Publication Date (W3CDTF): 2018-03-26
• Alternative Title: 多発性硬化症における皮質病変の臨床的意義：神経心理学および神経画像による研究
• Degree grantor/type: 三重大学
• Date Granted: 2018-03-26
• Date Granted (W3CDTF): 2018-03-26
• Dissertation Number: 甲医学第1895号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医学第1895号
• Text Language Code: eng
• Alias of Author: マツシタ, フトシ; 松下, 太
• Subject Heading: cognitive impairment; cortical lesions; magnetic resonance imaging; multiple sclerosis; neuropsychological tests
• Target Audience: 一般
• Note (General): application/pdf; Introduction: This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS).Methods: A total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non-CL. In-house software was used to quantitatively determine the atrophy of each brain region. Activities of daily living (ADL) were estimated using the Kurtzke Expanded Disability Status Scale (EDSS). Cognitive function was assessed using the following tests: Mini-Mental State Examination (MMSE), Trail Making Test (TMT), and Paced Auditory Serial Addition Task (PASAT). Z-scores were used to assess significant differences in the neuropsychological test outcomes between the groups.Results: Six of 19 patients had subcortical and deep WM lesions (non-CL group; diagnosed with relapsing-remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9-relapsing-remitting MS; 4-primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non-CL group. There were no significant differences in gray and white matter volume between the CL and the non-CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the non-CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data.Conclusions: Progressive MS, which was associated with decreased physical functioning, ADL, and cognitive impairment, was found in patients in the CL group.; 本文 / Department of Dementia Prevention and Therapeutics, Mie University; 30p
• DOI: info:doi/10.1002/brb3.934; https://doi.org/info:doi/10.1002/brb3.934
• Persistent ID (NDL): info:ndljp/pid/11123942; https://dl.ndl.go.jp/pid/11123942
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2018-07-23
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017717; https://mie-u.repo.nii.ac.jp/records/12085
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集