Nomogram for 5-year relapse-free survival of a patient with advanced gastric cancer after surgery

• Material Type: 博士論文
• Title: Nomogram for 5-year relapse-free survival of a patient with advanced gastric cancer after surgery
• Author/Editor: Muneoka, Yusuke
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-03-23
• Publication Date (W3CDTF): 2018-03-23
• Alternative Title: Nomogram for 5-year relapse-free survival of a patient with advanced gastric cancer after surgery; 進行胃癌に対する根治切除術後の再発予後予測ノモグラムの検討
• Degree grantor/type: 新潟大学
• Date Granted: 2018-03-23
• Date Granted (W3CDTF): 2018-03-23
• Dissertation Number: 甲第4396号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4396号
• Text Language Code: eng
• Subject Heading: Nomogram; Prediction; Advanced gastric cancer; Recurrence risk; Cox proportional hazards regression model
• Note (General): Background: Prognoses vary substantially among patients with advanced gastric cancer following curative surgery. The aim of the current study was to develop and verify the validity of a novel nomogram that predicts the probability of 5-year relapse-free survival (RFS) in patients who underwent curative resection for stage II/III gastric cancer. Materials and methods: A nomogram to predict 5-year RFS following surgical resection of gastric cancer was constructed based on the data of patients who underwent surgery for primary gastric carcinoma at three institutions in Japan in January 2001-December 2006. Multivariate analysis using a Cox proportional hazards regression model was performed, and the nomogram's predictive accuracy (discrimination) and the agreement between observed outcomes and predictions (calibration) were evaluated by internal validation. Results: Multivariate analyses revealed that age at operation, depth of tumor, tumor location, lymph node classification, and presence of combined resection were significant prognostic factors for RFS. In the internal validation, discrimination of the developed nomogram for 5-year RFS was superior to that of the American Joint Committee on Cancer TNM classification (concordance indices of 0.80 versus 0.67; P < 0.001). Moreover, calibration appeared to be accurate. Based on these results, we have created free software to more easily predict 5-year RFS. Conclusion: We developed and validated a nomogram to predict 5-year RFS after curative surgery for stage II/III gastric cancer. This tool will be useful for the assessing a patient's individual recurrence risk when considering additional therapy in clinical practice.; 学位の種類: 博士（医学）. 報告番号: 甲第4396号. 学位記番号: 新大院博（医）甲第795号. 学位授与年月日: 平成30年3月23日; International Journal of Surgery. 2016. 35, 153-159.; 新大院博（医）甲第795号; 元資料の権利情報 : Elsevier; 開始ページ : 153; 終了ページ : 159
• DOI: info:doi/10.1016/j.ijsu.2016.09.080; https://doi.org/info:doi/10.1016/j.ijsu.2016.09.080
• Persistent ID (NDL): info:ndljp/pid/11123986; https://dl.ndl.go.jp/pid/11123986
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-08-03T23:36:01+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/50434
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp