Deletion status of p16 in effusion smear preparation correlates with that of underlying malignant pleural mesothelioma tissue

• Material Type: 博士論文
• Title: Deletion status of p16 in effusion smear preparation correlates with that of underlying malignant pleural mesothelioma tissue
• Author/Editor: 樋田, 知之
• Author Heading: 樋田, 知之
• Publication Date: 2017-03-24
• Publication Date (W3CDTF): 2017-03-24
• Alternative Title: 悪性胸膜中皮腫の p16 遺伝子の欠失状態は胸水塗抹標本と組織標本で相関する
• Contributor: 中西, 洋一; 赤司, 浩一; 續, 輝久
• Degree grantor/type: 九州大学
• Date Granted: 2017-03-24
• Date Granted (W3CDTF): 2017-03-24
• Dissertation Number: 甲第13390号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13390号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Differentiating malignant pleural mesothelioma (MPM) cells morphologically from reactive mesothelial hyperplasia cells is problematic. Homozygous deletion (HD) of p16 (CDKN2A), detected by FISH, is a good marker of malignancy and is useful to differentiate between these cells. However, the correlation between the p16 status of effusion smears and that of the underlying MPM tissues has not been investigated. We used p16-specific FISH to investigate 20 cases of MPM from which both effusion cytologic smears and histologic specimens were available. In five cases, histologic specimens included both an invasive component and surface mesothelial proliferation. In 14 cases (70%), MPM cells in both tissue sections and effusion smears were p16 HD-positive. Conversely, MPM cells in the remaining six tumors (30%) were p16 HD-negative in both tissue sections and effusion smears. For all five MPM cases with surface mesothelial proliferations and invasive components, the effusion smears, surface mesothelial proliferations, and invasive MPM components all displayed p16 deletion. Moreover, the extent to which p16 was deleted in smears highly correlated with the extent of p16 deletion in tissues. The p16 deletion percentages were also similar among smears, tissue surface proliferations, and invasive components. In cases with clinical and radiologic evidence of a diffuse pleural tumor, detection of p16 deletion in cytologic smear samples may permit MPM diagnosis without additional tissue examination. However, the absence of p16 deletion in cytologic smear samples does not preclude MPM.; PubMed番号 : 26291840
• DOI: info:doi/10.1111/cas.12769; https://doi.org/info:doi/10.1111/cas.12769
• Persistent ID (NDL): info:ndljp/pid/11150698; https://dl.ndl.go.jp/pid/11150698
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
• Date Created (W3CDTF): 2017-05-12
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/2324/1806882
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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