肺動脈性肺高血圧症患者における肺MIBG取り込み低下

• Material Type: 博士論文
• ISSN: 1349-2365
• Title: 肺動脈性肺高血圧症患者における肺MIBG取り込み低下
• Volume: 59 1
• Author/Editor: 肥後, 建樹郎
• Author Heading: 肥後, 建樹郎
• Publication, Distribution, etc.: International Heart Journal Association
• Publication Date: 2018; 59 1
• Publication Date (W3CDTF): 2018
• Alternative Title: Impairment of iodine-123-metaiodobenzylguanidine (123I-MIBG) uptake in patients with pulmonary artery hypertension
• Periodical title: International Heart Journal
• Degree grantor/type: 鹿児島大学
• Date Granted: 2017-09-29
• Date Granted (W3CDTF): 2017-09-29
• Dissertation Number: 甲総研第429号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第429号
• Text Language Code: eng
• Subject Heading: Pulmonary hypertension; 123I-MIBG scintigraphy; Endothelial dysfunction
• NDC: 493
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; According to recent studies, lung uptake of iodine-123-metaiodobenzylguanidine (123I-MIBG) is impaired in many lung diseases and low lung uptake of 123I-MIBG suggests endothelial dysfunction of the pulmonary artery.123I-MIBG scintigraphy in patients with pulmonary hypertension (PH) has not yet been clinically evaluated. We hypothesized that the lung uptake of 123I-MIBG is reduced in patients with PH and differs among PH subtypes. The purpose of the present study was to analyze the lung uptake of 123I-MIBG in patients with PH and compare it with the data obtained by echocardiography or right heart catheterization. 123I-MIBG scintigraphy was performed in 286 consecutive patients from 2003 to 2014. We enrolled 21 patients with PH and 8 control patients.The 21 patients with PH were categorized into those with pulmonary artery hypertension(PAH, n=12) and those with chronic thromboembolic pulmonary hypertension (CTEPH, n=9). The mean pulmonary artery pressure was not significantly different between patients with CTEPH and PAH (37.7 ± 6.8 versus 32.3 ± 5.3 mmHg respectively; P=0.054). There were no significant differences in any other hemodynamic parameters between the two groups.The lung uptake of 123I-MIBG in PAH patients (early image: 1.54 ± 0.18, delayed image: 1.41 ± 0.16) was significantly lower than that of CTEPH patients (early image: 2.17 ± 0.25,P<0.0001; delayed image: 1.99 ± 0.20, P=0.0001, adjusted for ageand World Health Organization classification) and controls(early image: 2.32 ± 0.27, P=0.0007; delayed image: 1.92 ± 0.19,P=0.0007). In conclusion, we found for the first time that the lung uptake of 123I-MIBG in patients with PAH is lower than that in patients with CTEPH and controls.
• Persistent ID (NDL): info:ndljp/pid/11150724; https://dl.ndl.go.jp/pid/11150724
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
• Date Created (W3CDTF): 2017-10-10
• Format (IMT): PDF; text/html; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.jstage.jst.go.jp/browse/ihj/
• Periodical Title (URI): http://hdl.handle.net/10232/00029887
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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