Defects in dosage compensation impact global gene regulation in the mouse trophoblast

• Material Type: 博士論文
• Title: Defects in dosage compensation impact global gene regulation in the mouse trophoblast
• Author/Editor: 酒田, 祐佳
• Author Heading: 酒田, 祐佳
• Publication Date: 2018-01-31
• Publication Date (W3CDTF): 2018-01-31
• Alternative Title: 遺伝子量補償の破たんはマウス栄養膜細胞における遺伝子発現制御に広範な影響を及ぼす
• Contributor: 林, 克彦; 加藤, 聖子; 目野, 主税
• Degree grantor/type: 九州大学
• Date Granted: 2018-01-31
• Date Granted (W3CDTF): 2018-01-31
• Dissertation Number: 甲第13898号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第13898号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Xist RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved in Xist RNA, the A-repeat has been shown to be essential for its silencing function in differentiating embryonic stem cells. Here, we introduced a new Xist allele into mouse that produces mutated Xist RNA lacking the A-repeat (Xist^<CAGΔ5'> ). Xist^<CAGΔ5'> RNA expressed in the embryo coated the X chromosome but failed to silence it. Although imprinted X inactivation was substantially compromised upon paternal transmission, allele-specific RNA-seq in the trophoblast revealed that Xist^<CAGΔ5'> RNA still retained some silencing ability. Furthermore, the failure of imprinted X inactivation had more significant impacts than expected on genome-wide gene expression. It is likely that dosage compensation is required not only for equalizing X-linked gene expression between the sexes but also for proper global gene regulation in differentiated female somatic cells.; PubMed番号 : 28684628
• DOI: 10.15017/1931751; https://doi.org/10.15017/1931751
• Persistent ID (NDL): info:ndljp/pid/11150798; https://dl.ndl.go.jp/pid/11150798
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
• Date Created (W3CDTF): 2018-05-30
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://dx.doi.org/10.15017/1931751; http://hdl.handle.net/2324/1931751
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

• Summary, etc.: Xist RNA, which is responsible for X inactivation, is a key epigenetic player in the embryogenesis of female mammals. Of the several repeats conserved...

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