硫化水素によるクラウン系ミニブタ腎虚血再灌流障害抑制効果

• Material Type: 博士論文
• Title: 硫化水素によるクラウン系ミニブタ腎虚血再灌流障害抑制効果
• Volume: 219
• Author/Editor: 関島, 光裕
• Author Heading: 関島, 光裕
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2017; 219
• Publication Date (W3CDTF): 2017
• Alternative Title: Hydrogen Sulfide Prevents Renal Ischemia-Reperfusion Injury in CLAWN Miniature Swine
• Periodical title: Journal of Surgical Research
• Degree grantor/type: 鹿児島大学
• Date Granted: 2018-04-26
• Date Granted (W3CDTF): 2018-04-26
• Dissertation Number: 甲総研第460号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第460号
• Text Language Code: eng
• Subject Heading: Hydrogen sulfide; Ischemia-reperfusion injury; Large animal model; Proinflammatory cytokines
• NDC: 490
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; Background: Hydrogen sulfide (H2S) has recently been reported to demonstrate both antiinflammatory and cytoprotective effects; however, its efficacy has not been well documented in large animal models. In this study, we examined whether the administration of H2S offers cytoprotective effects on renal ischemia-reperfusion injury (IRI) in a preclinical miniature swine model.Methods: Major histocompatibility complex-inbred, CLAWN miniature swine (n=9) underwent a right nephrectomy, followed by induction of a 120-min period of warm ischemia via placement of clamps on the left renal artery and vein. Group 1 (n=3) underwent renal ischemiawithout H2S administration. Groups 2 (n=3) and 3 (n=3) received Na2S (prodrug of H2S) 10 min before reperfusion of the ischemic kidneys followed by a 30-min of Na2S postreperfusion intravenously (group 2) or selective administration of Na2S via the left renalartery(group 3).IRIwas assessed by kidney biopsies, levels of inflammatory cytokines in sera and kidney tissue.Results: Animals in group 1 had significantly higher serum creatinine levels compared with animals in groups 2 and 3 (P<0.01). Histology showed severe tubular damage with TUNEL-positive cells in group 1 on postoperative day 2 compared with mild damage in group 2 and minimal damage in group 3. Further more, levels of inflammatory cytokines in both serum (interleukin-6 [IL-6], tumor necrosis factor-α, and high-mobility group box 1) and renal tissue (IL-1 and IL-6) in group 3 were markedly lower than in group 2, suggesting beneficial effects of selective Na2S administration.Conclusions: Na2S administration, especially via an organ selective approach, appears to potentially offer cytoprotective and antiinflammatory effects following rena lIRI.
• Persistent ID (NDL): info:ndljp/pid/11150842; https://dl.ndl.go.jp/pid/11150842
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
• Date Created (W3CDTF): 2018-07-11
• Format (IMT): PDF; text/html; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.sciencedirect.com/journal/journal-of-surgical-research
• Periodical Title (URI): http://hdl.handle.net/10232/00030308
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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