Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure : results of a nationwide survey of adult patients

Persistent ID (NDL): info:ndljp/pid/11150963

Material type: 博士論文

Author: 脇, 房子

Publisher: -

Publication date: 2016-06-28

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: To evaluate whether rescue with cord blood transplantation (CBT) could improve the poor survival after graft failure (GF), we surveyed the data of 80 ...

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Material Type: 博士論文
Title: Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure : results of a nationwide survey of adult patients
Author/Editor: 脇, 房子
Author Heading: 脇, 房子
Publication Date: 2016-06-28
Publication Date (W3CDTF): 2016-06-28
Degree grantor/type: 香川大学
Date Granted: 2016-06-28
Date Granted (W3CDTF): 2016-06-28
Dissertation Number: 甲第644号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第644号
Text Language Code: eng
Alias of Author: Waki, Fusako
Subject Heading: Graft failure
Rejection
Reduced intensity
Allogeneic stem cell transplantation
Cord blood transplantation
Target Audience: 一般
Note (General): To evaluate whether rescue with cord blood transplantation (CBT) could improve the poor survival after graft failure (GF), we surveyed the data of 80 adult patients (median age, 51 years) who received CBT within 3 months of GF (primary 64, secondary 16), with fludarabine-based reduced-intensity regimens with or without melphalan, busulfan, cyclophosphamide, and/or 2-4 Gy total-body irradiation (TBI). A median number of 2.4 × 107/kg total nucleated cells (TNC) were infused, and among the 61 evaluable patients who survived for more than 28 days, 45 (74%) engrafted. The median follow-up of surviving patients was 325 days, and the 1-year overall survival rate was 33% despite poor performance status (2-4, 60%), carryover organ toxicities (grade 3/4, 14%), and infections (82%) prior to CBT. Day 100 transplantation-related mortality was 45%, with 60% related to infectious complications. Multivariate analysis showed that the infusion of TNC ≥2.5 × 107/kg and an alkylating agent–containing regimen were associated with a higher probability of engraftment, and that high risk-status at the preceding transplantation and grade 3/4 organ toxicities before CBT were associated with an increased risk of mortality. In conclusion, in an older population of patients, our data support the feasibility of CBT with a reduced-intensity conditioning regimen for GF.
DOI: info:doi/10.1016/j.bbmt.2010.09.005
https://doi.org/info:doi/10.1016/j.bbmt.2010.09.005
Persistent ID (NDL): info:ndljp/pid/11150963
https://dl.ndl.go.jp/pid/11150963
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/326
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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