Study on the Effect of Obesity on Epithelial Defense against Cancer

Persistent ID (NDL): info:ndljp/pid/11151080

Material type: 博士論文

Author: 佐々木, 彩名

Publisher: Hokkaido University

Publication date: 2018-06-29

Material Format: Digital

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Name of awarding university/degree: 北海道大学,博士(理学)

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Note (General)：: Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelial tissues via cell competition with the surround...

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Material Type: 博士論文
Title: Study on the Effect of Obesity on Epithelial Defense against Cancer
Author/Editor: 佐々木, 彩名
Author Heading: 佐々木, 彩名
Publication, Distribution, etc.: Hokkaido University
Publication Date: 2018-06-29
Publication Date (W3CDTF): 2018-06-29
Alternative Title: 上皮細胞に備わる発がん防御機構[EDAC]における肥満の影響に関する研究
Study on the Effect of Obesity on Epithelial Defense against Cancer (EDAC)
Contributor: 村上, 洋太
髙木, 睦
髙岡, 晃教
藤田, 恭之
Degree grantor/type: 北海道大学
Date Granted: 2018-06-29
Date Granted (W3CDTF): 2018-06-29
Dissertation Number: 甲第13277号
Degree Type: 博士(理学)
Conferring No. (Dissertation): 甲第13277号
Text Language Code: eng
Alias of Author: Sasaki, Ayana
NDC: 400
Target Audience: 一般
Note (General): Recent studies have revealed that newly emerging transformed cells are often eliminated from epithelial tissues via cell competition with the surrounding normal epithelial cells. This cancer preventive phenomenon is termed Epithelial Defense Against Cancer (EDAC). However, it remains largely unknown whether and how EDAC is diminished during carcinogenesis. In this study, using a newly established cell competition mouse model, I show that high-hat diet (HFD)-feeding substantially attenuates the frequency of apical elimination of RasV12-transformed cells from intestinal and pancreatic epithelia, leading to the formation of precancerous tumors. This process involves both lipid metabolism and chronic inflammation. Furthermore, aspirin treatment significantly facilitates eradication of transformed cells from the epithelial tissues in HFD-fed mice. This is the first report demonstrating that obesity can profoundly influence competitive interaction between normal and transformed cells, providing new insights into cell competition and cancer preventive medicine.
(主査) 教授村上洋太, 教授髙木睦, 教授髙岡晃教, 教授藤田恭之
総合化学院（総合化学専攻）
DOI: 10.14943/doctoral.k13277
https://doi.org/10.14943/doctoral.k13277
Persistent ID (NDL): info:ndljp/pid/11151080
https://dl.ndl.go.jp/pid/11151080
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-09-03T21:27:21+09:00
Date Created (W3CDTF): 2018
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://dx.doi.org/10.14943/doctoral.k13277
http://hdl.handle.net/2115/71327
Is Referenced By (URI): http://hdl.handle.net/2115/71325
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
https://dl.ndl.go.jp