カニクイザルを用いた大腸菌由来リポポリサッカライド(LPS)投与による播種性血管内凝固症候群(DIC)モデル作成及びその病態解析

• Material Type: 博士論文
• Title: カニクイザルを用いた大腸菌由来リポポリサッカライド(LPS)投与による播種性血管内凝固症候群(DIC)モデル作成及びその病態解析
• Volume: 133 2
• Author/Editor: 蓑毛, 博文
• Author Heading: 蓑毛, 博文
• Publication, Distribution, etc.: Japanese Pharmacological Society
• Publication Date: 2017; 133 2
• Publication Date (W3CDTF): 2017
• Alternative Title: Establishment of Disseminated Intravascular Coagulation (DIC) Model by a Single iv Administration of E. coli-derived Lipopolysaccharide (LPS) to Cynomolgus Monkeys and Evaluation of its Pathophysiological Status
• Periodical title: Journal of Pharmacological Sciences
• Degree grantor/type: 鹿児島大学
• Date Granted: 2017-09-29
• Date Granted (W3CDTF): 2017-09-29
• Dissertation Number: 甲総研第433号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 甲総研第433号
• Text Language Code: eng
• Subject Heading: Thrombomodulin; LPS; DIC
• NDC: 493
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; We prepared a DIC model by administrating LPS to cynomolgus monkeys, and investigated its potential for evaluations of new medicines for DIC therapy. Peripheral blood mononuclear cells (PBMC) collected from cynomolgus monkeys were incubated with LPS (8 types), and TNF-α levels in the media were measured. LPS from E. coli (K-235) was most appropriate in terms of larger increases and smaller variation in TNF-α levels. PBMC from rats, cynomolgus monkeys or humans were incubated with LPS (K-235), and the TNF-α response to LPS was investigated. The response was comparable between cynomolgus monkeys and humans but small in rats. In an in vivo experiment, LPS (K-235) was administered once intravenously to cynomolgus monkeys with or without recombinant human thrombomodulin (rhTM) to investigate any changes in coagulation and fibrinolysis biomarkers and the suppressive effect of rhTM. The liver, kidney, and lung were examined histopathologically. Almost all of the changes resembled the pathophysiological status of human DIC and were suppressed by co-administration of rhTM. The DIC model resembling human DIC was established by LPS (K-235) treatment in cynomolgus monkeys, and therapeutic effect of rhTM was noted, suggesting that this model is useful in evaluations of the efficacy of new medicines for DIC therapy.
• Persistent ID (NDL): info:ndljp/pid/11162923; https://dl.ndl.go.jp/pid/11162923
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-10-03T17:18:55+09:00
• Date Created (W3CDTF): 2017-10-10
• Format (IMT): PDF; text/html; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.sciencedirect.com/journal/journal-of-pharmacological-sciences
• Periodical Title (URI): http://hdl.handle.net/10232/00029891
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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