Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.

• Material Type: 博士論文
• ISSN: 2045-2322
• Title: Increased arachidonic acid-containing phosphatidylcholine is associated with reactive microglia and astrocytes in the spinal cord after peripheral nerve injury.
• Volume: 6
• Author/Editor: 徐, 冬閩
• Author Heading: 徐, 冬閩
• Publication, Distribution, etc.: Nature Publishing Group
• Publication Date: 2016-03-23
• Publication Date (W3CDTF): 2016-03-23
• Alternative Title: 末梢神経損傷後のアラキドン酸含有ホスファチジルコリンの増加は脊髄内の活性化ミクログリアとアストロサイトに関連している
• Periodical title: Scientific Reports
• Degree grantor/type: 浜松医科大学
• Date Granted: 2017-09-22
• Date Granted (W3CDTF): 2017-09-22
• Dissertation Number: 甲第764号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第764号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): doctoral; 医学系研究科; Peripheral nerve injury (PNI) triggers cellular and molecular changes in the spinal cord. However, little is known about how the polyunsaturated fatty acid-containing phosphatidylcholines (PUFA-PCs) are regulated in the spinal cord after PNI and the association of PUFA-PCs with the non-neuronal cells within in the central nervous system (CNS). In this study, we found that arachidonic acid-containing phosphatidylcholine (AA-PC), [PC(16:0/20:4)+K]+, was significantly increased in the ipsilateral ventral and dorsal horns of the spinal cord after sciatic nerve transection, and the increased expression of [PC(16:0/20:4)+K]+ spatiotemporally resembled the increase of reactive microglia and the astrocytes. From the lipidomics point of view, we conclude that [PC(16:0/20:4)+K]+ could be the main phospholipid in the spinal cord influenced by PNI, and the regulation of specific phospholipid molecule in the CNS after PNI is associated with the reactive microglia and astrocytes.
• DOI: info:doi/10.1038/srep26427; https://doi.org/info:doi/10.1038/srep26427
• Persistent ID (NDL): info:ndljp/pid/11164081; https://dl.ndl.go.jp/pid/11164081
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-10-03T17:18:55+09:00
• Date Created (W3CDTF): 2018-09-13
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10271/00003396; https://hama-med.repo.nii.ac.jp/records/3250
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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