Phenotypic characterization and clinical outcome in ampullary adenocarcinoma

• Material Type: 博士論文
• Title: Phenotypic characterization and clinical outcome in ampullary adenocarcinoma
• Author/Editor: 浅野, 栄介
• Author Heading: 浅野, 栄介
• Publication Date: 2016-09-29
• Publication Date (W3CDTF): 2016-09-29
• Degree grantor/type: 香川大学
• Date Granted: 2016-09-29
• Date Granted (W3CDTF): 2016-09-29
• Dissertation Number: 甲第645号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第645号
• Text Language Code: eng
• Alias of Author: Asano, Eisuke
• Subject Heading: ampullary adenocarcinoma; β‐catenin; p53; pathologic subtype; mixed type
• Target Audience: 一般
• Note (General): BackgroundAlthough various features of ampullary adenocarcinoma have been reported, the impact of genetic alterations and rare subtypes on clinical outcome remains unclear.; MethodsWe determined the expression of proteins, including MUC1, MUC2, p53, p16, Smad/Dpc4, and β‐catenin, and genetic mutations such as KRAS, BRAF, and GNAS mutations in 69 patients with ampullary adenocarcinoma to clarify their relationships with clinicopathological findings and subtypes.; ResultsKaplan–Meier survival analysis indicated that abnormal p53 labeling was significantly associated with a shorter overall survival. MUC1‐positive and MUC2‐negative expressions were significantly associated with lymphatic invasion, pancreatic invasion, lymph node metastasis, and advanced UICC stage. The KRAS mutation was significantly associated with large tumor size and pancreatic invasion. There were 35 intestinal (50%), 15 pancreatobiliary (22%), and 11 mixed subtype (16%) tumors. Patients with the mixed subtype showed significantly poor outcome. The invasiveness of the mixed subtype was similar to that of the pancreatobiliary subtype; moreover, the mixed subtype showed a high incidence of abnormal β‐catenin immunolabeling (73%).; ConclusionsProtein expression and genetic mutation are clinically associated with the characteristics of ampullary adenocarcinoma. The mixed subtype may have a distinct tumor nature as compared to other two major subtypes.
• DOI: info:doi/10.1002/jso.24274; https://doi.org/info:doi/10.1002/jso.24274
• Persistent ID (NDL): info:ndljp/pid/11164126; https://dl.ndl.go.jp/pid/11164126
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-10-03T17:18:55+09:00
• Date Created (W3CDTF): 2020-10-27
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/329
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-08-05 再収集