Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model

• Material Type: 博士論文
• ISSN: 0022-4804
• Title: Adipose-derived mesenchymal stem cells attenuate rejection in a rat lung transplantation model
• Volume: 227
• Author/Editor: 渡邉, 洋之助
• Author Heading: 渡邉, 洋之助
• Publication, Distribution, etc.: Elsevier Inc.
• Publication Date: 2018-09-05
• Publication Date (W3CDTF): 2018-09-05
• Alternative Title: 脂肪由来間葉系幹細胞はラット肺移植モデルにおいて拒絶を抑制する
• Periodical title: Journal of Surgical Research
• Degree grantor/type: Nagasaki University (長崎大学)
• Date Granted: 2018-09-05
• Date Granted (W3CDTF): 2018-09-05
• Dissertation Number: 甲医歯薬第1089号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 甲医歯薬第1089号
• Text Language Code: eng
• Subject Heading: Adipose tissue?derived mesenchymal stem cell; Lung transplantation; Hepatocyte growth factor
• Target Audience: 一般
• Note (General): Background: Immunosuppression following lung transplantation is a key aspect to the graft's survival. However, the well-known complications that are caused by immunosuppressive regimens present an opportunity to study ways to minimize the usage of these drugs. Recently, a promising discovery has been made pertaining to the immunomodulatory effects of adipose tissue?derived mesenchymal stem cells (ADMSCs) through their secretion of hepatocyte growth factor. In the hopes of mitigating the adverse effects of standard immunosuppressive regimens, our study aims to investigate the effects of ADMSCs on the immune response utilizing a rat lung transplantation model. Methods: Each rat's own ADMSCs were intravenously administered immediately after orthotopic left lung transplantation. The experimental subjects were divided into four groups: 1) control group (group C) was administered no treatment following transplantation; 2) ADMSC group (group A), administered a single intravenous injection of ADMSCs following transplantation; 3) tacrolimus group (group T), administered tacrolimus (0.5 mg/kg) every 24 h following transplantation; and 4) ADMSC and tacrolimus group (AT group) administered a single intravenous injection of ADMSCs in combination with tacrolimus every 24 h following transplantation. Results: The histologically proven rejection grade in group AT was significantly lower than that in group T. The serum levels of hepatocyte growth factor and the expression of cMet in group AT accompanied by low CD40 expression were also significantly higher than those of the lung grafts of group T. Conclusions: These results suggest that co-administration of ADMSCs with tacrolimus is a beneficial therapeutic approach in lung transplantation.; 長崎大学学位論文 学位記番号:博(医歯薬)甲第1089号 学位授与年月日:平成30年9月5日; Author: Hironosuke Watanabe, Tomoshi Tsuchiya, Koichiro Shimoyama, Akira Shimizu, Sadanori Akita, Hiroshi Yukawa, Yoshinobu Baba, and Takeshi Nagayasu; Citation: Journal of Surgical Research, 227, pp.17-27; 2018; Nagasaki University (長崎大学), 博士(医学) (2018-09-05)
• DOI: info:doi/10.1016/j.jss.2018.01.016; https://doi.org/info:doi/10.1016/j.jss.2018.01.016
• Persistent ID (NDL): info:ndljp/pid/11164143; https://dl.ndl.go.jp/pid/11164143
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-10-03T17:18:55+09:00
• Date Created (W3CDTF): 2020-12-18
• Format (IMT): PDF
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10069/38576; https://nagasaki-u.repo.nii.ac.jp/records/1313
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

Table of Contents

2021-03-07 再収集