Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis

• Material Type: 博士論文
• ISSN: 1868-6974
• Title: Loss of Fbxw7 expression is a predictor of recurrence in colorectal liver metastasis
• Volume: 24 10
• Author/Editor: Kawashita, Yoichiro; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Iwahashi, Shuichi; Yamada, Shinichiro; Higashijima, Jun; Imura, Satoru; Ogawa, Hirohisa; Yagi, Toshiyuki; Shimada, Mitsuo
• Author Heading: Kawashita, Yoichiro; Morine, Yuji; Ikemoto, Tetsuya; Saito, Yu; Iwahashi, Shuichi; Yamada, Shinichiro; Higashijima, Jun; Imura, Satoru; Ogawa, Hirohisa; Yagi, Toshiyuki; Shimada, Mitsuo
• Publication, Distribution, etc.: Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
• Publication Date: 2017-08-28
• Publication Date (W3CDTF): 2017-08-28
• Alternative Title: Fbxw7発現低下は大腸癌肝転移切除症例の再発予測因子である
• Periodical title: Journal of Hepato-Biliary-Pancreatic Sciences
• Degree grantor/type: 徳島大学
• Date Granted: 2017-11-30
• Date Granted (W3CDTF): 2017-11-30
• Dissertation Number: 甲第3120号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第3120号
• Text Language Code: eng
• Subject Heading: Colorectal liver metastasis; Fbxw7; miR-223; Prognostic factor
• Target Audience: 一般
• Note (General): Background/PurposeFbxw7 is a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of Fbxw7 is frequently observed in various human cancers. In this study, we examined the role of Fbxw7 expression in colorectal liver metastasis (CRLM) and its mechanism.MethodsFifty-six patients with CRLM who undergo curative resection were enrolled. Fbxw7 in tumor tissue was determined by immunohistochemistry. Patients were divided into two groups, the Fbxw7 high and low group. Clinicopathological factors including miR-223 expression were compared between the high (n=32) and low Fbxw7 group (n=24).ResultsFbxw7 expression in tumor tissues was significantly lower than that in normal tissues. The disease-free survival in the low Fbxw7 group was significantly worse than that in the high Fbxw7 group, and 3years disease-free survival of the low and the high Fbxw7 group were 12.5% and 47.0%, respectively (p=0.023). On multivariate analysis, loss of Fbxw7 was detected as one of the independent risk factor for recurrence of CRLM (Hazard ratio: 2.390, p=0.017). Likewise, Fbxw7 expression inversely correlated to miR-223 expression (p=0.017).ConclusionLoss of Fbxw7 in tumor tissues could be a reliable predictor of recurrence after hepatectomy in patients with CRLM, and miR223 might be a possible regulator of Fbxw7.
• DOI: info:doi/10.1002/jhbp.500; https://doi.org/info:doi/10.1002/jhbp.500
• Persistent ID (NDL): info:ndljp/pid/11178396; https://dl.ndl.go.jp/pid/11178396
• Collection: 障害者向け資料
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-11-05T10:48:21+09:00
• Format (IMT): application/pdf
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• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/110995
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp