Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation

• Material Type: 博士論文
• Title: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
• Author/Editor: カスティーヨ, カリオン, エリカ, カテリン
• Author Heading: カスティーヨ, カリオン, エリカ, カテリン
• Publication Date: 2018-06-30
• Publication Date (W3CDTF): 2018-06-30
• Alternative Title: アルツハイマー病患者とマウスモデルの大脳皮質における遺伝子発現の比較プロファイリングから明らかになったアミロイドーシスと神経炎症の関係
• Degree grantor/type: 九州大学
• Date Granted: 2018-06-30
• Date Granted (W3CDTF): 2018-06-30
• Dissertation Number: 甲第14151号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第14151号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Alzheimer's disease (AD) is the most common form of dementia, characterized by accumulation of amyloid β (Aβ) and neurofibrillary tangles. Oxidative stress and inflammation are considered to play an important role in the development and progression of AD. However, the extent to which these events contribute to the Aβ pathologies remains unclear. We performed inter-species comparative gene expression profiling between AD patient brains and the App^<NL-G-F/NL-G-F> and 3xTg-AD-H mouse models. Genes commonly altered in App^<NL-G-F/NL-G-F> and human AD cortices correlated with the inflammatory response or immunological disease. Among them, expression of AD-related genes (C4a/C4b, Cd74, Ctss, Gfap, Nfe2l2, Phyhd1, S100b, Tf, Tgfbr2, and Vim) was increased in the App^<NL-G-F/NL-G-F> cortex as Aβ amyloidosis progressed with exacerbated gliosis, while genes commonly altered in the 3xTg-AD-H and human AD cortices correlated with neurological disease. The App^<NL-G-F/NL-G-F> cortex also had altered expression of genes (Abi3, Apoe, Bin2, Cd33, Ctsc, Dock2, Fcer1g, Frmd6, Hck, Inpp5D, Ly86, Plcg2, Trem2, Tyrobp) defined as risk factors for AD by genome-wide association study or identified as genetic nodes in late-onset AD. These results suggest a strong correlation between cortical Aβ amyloidosis and the neuroinflammatory response and provide a better understanding of the involvement of gender effects in the development of AD.; PubMed番号 : 29259249
• DOI: info:doi/10.1038/s41598-017-17999-3; https://doi.org/info:doi/10.1038/s41598-017-17999-3
• Persistent ID (NDL): info:ndljp/pid/11178474; https://dl.ndl.go.jp/pid/11178474
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-11-05T10:48:21+09:00
• Date Created (W3CDTF): 2018-08-07
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/2324/1937180
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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