Gene expression changes in the retina after systemic administration of aldosterone

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Gene expression changes in the retina after systemic administration of aldosterone

Persistent ID (NDL): info:ndljp/pid/11178632

Material type: 博士論文

Author: 小野, 葵

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Publication date: 2018-09-27

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: PurposeRetinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs a...

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Material Type: 博士論文
Title: Gene expression changes in the retina after systemic administration of aldosterone
Author/Editor: 小野, 葵
Author Heading: 小野, 葵
Publication Date: 2018-09-27
Publication Date (W3CDTF): 2018-09-27
Degree grantor/type: 香川大学
Date Granted: 2018-09-27
Date Granted (W3CDTF): 2018-09-27
Dissertation Number: 甲第697号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第697号
Text Language Code: eng
Alias of Author: Ono, Aoi
Subject Heading: Aldosterone
Retinal ganglion cell
Microarray
Retina
Glaucoma
Target Audience: 一般
Note (General): PurposeRetinal ganglion cell (RGC) loss associated with thinning of the retinal nerve fiber layer without elevated intraocular pressure (IOP) occurs after the systemic administration of aldosterone. Since it is important to determine the mechanism of cell death independent of the IOP, we examined gene expression changes in the retina after the systemic administration of aldosterone.
MethodsFollowing subcutaneous implantation of an osmotic minipump into the mid-scapular region of rats, we administered an 80 μg/kg/day dose of aldosterone. Differences in the gene expression in the retina between normal rats and aldosterone-treated rats were investigated using microarrays. Real-time PCR was used to confirm the differential expression.
ResultsAnalysis of the microarray data sets revealed the upregulation of 24 genes and the downregulation of 24 genes of key apoptosis-specific genes. Real-time PCR revealed 4 genes (Cdkn1a, Tbox5, Pf4, Vdr) were upregulated while 12 genes (Acvr1c, Asns, Bard1, Card9, Crh, Fcgr1a, Inhba, Kcnh8, Lck, Phlda1, Ptprc, Sh3rf1) were downregulated.
ConclusionsSignificant increases and decreases were noted in several genes after the systemic administration of aldosterone. Further studies will need to be undertaken in order to definitively clarify the role of these genes in the eyes of animals with normal-tension glaucoma.
DOI: info:doi/10.1007/s10384-018-0595-4
https://doi.org/info:doi/10.1007/s10384-018-0595-4
Persistent ID (NDL): info:ndljp/pid/11178632
https://dl.ndl.go.jp/pid/11178632
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2018-11-05T10:48:21+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/334
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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