Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study

• Material Type: 博士論文
• Title: Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study
• Author/Editor: Nakayama, Yoko
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2017-09-20
• Publication Date (W3CDTF): 2017-09-20
• Alternative Title: Features of amygdala in patients with mesial temporal lobe epilepsy and hippocampal sclerosis : an MRI volumetric and histopathological study; 内側側頭葉てんかんおよび海馬硬化症における扁桃体の体積定量および病理組織学的研究
• Degree grantor/type: 新潟大学
• Date Granted: 2017-09-20
• Date Granted (W3CDTF): 2017-09-20
• Dissertation Number: 甲第4353号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4353号
• Text Language Code: eng
• Subject Heading: amygdala; Bcl-2; hippocampal sclerosis; HSP70; mesial temporal epilepsy
• Note (General): Objective: It is well-known that there is a correlation between the neuropathological grade of hippocampal sclerosis (HS) and neuroradiological atrophy of the hippocampus in mesial temporal lobe epilepsy (mTLE) patients. However, there is no strict definition or criterion regarding neuron loss and atrophy of the amygdala neighboring the hippocampus. We examined the relationship between HS and neuronal loss in the amygdala. Materials and Methods: Nineteen mTLE patients with neuropathological proof of HS were assigned to Group A, while seven mTLE patients without HS were assigned to Group B. We used FreeSurfer software to measure amygdala volume automatically based on pre-operation magnetic resonance images. Neurons observed using Kluver-Barrera (KB) staining in resected amygdala tissue were counted. and the extent of immunostaining with stress marker antibodies was semiquantitatively evaluated. Results: There was no significant difference in amygdala volume between the two groups (Group A: 1.41 ± 0.24; Group B: 1.41 ± 0.29 cm^3; p= 0.98), nor in the neuron cellularity of resected amygdala specimens (Group A: 3.98 ± 0.97; Group B: 3.67 ± 0.67 10×^<-4> number of neurons/μm^2; p= 0.40). However, the HSP70 level, representing acute stress against epilepsy, in Group A patients was significantly larger than that in Group B. There was no significant difference in the level of Bcl-2, which is known as a protein that inhibits cell death, between the two groups. Conclusions: Neuronal loss and volume loss in the amygdala may not necessarily follow hippocampal sclerosis. From the analysis of stress proteins, epileptic attacks are as likely to damage the amygdala as the hippocampus but do not lead to neuronal death in the amygdala.; 学位の種類: 博士（医学）. 報告番号: 甲第4353号. 学位記番号: 新大院博（医）甲第766号. 学位授与年月日: 平成29年9月20日; Epilepsy Research. 2017, 135, 50-55.; 新大院博（医）甲第766号; 元資料の権利情報 : (C) 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
• DOI: info:doi/10.1016/j.eplepsyres.2017.05.010; https://doi.org/info:doi/10.1016/j.eplepsyres.2017.05.010
• Persistent ID (NDL): info:ndljp/pid/11194451; https://dl.ndl.go.jp/pid/11194451
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2018-12-03T16:15:19+09:00
• Date Created (W3CDTF): 2019-08-05
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/48145
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp