Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers

• Material Type: 博士論文
• Title: Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers
• Author/Editor: Seino, Satoshi
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-09-20
• Publication Date (W3CDTF): 2018-09-20
• Alternative Title: Clinical outcome of hepatocellular carcinoma can be predicted by the expression of hepatic progenitor cell markers and serum tumour markers; 肝前駆細胞マーカーの発現と血清腫瘍マーカーにより肝細胞癌の臨床的悪性度が推測できる
• Degree grantor/type: 新潟大学
• Date Granted: 2018-09-20
• Date Granted (W3CDTF): 2018-09-20
• Dissertation Number: 甲第4492号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4492号
• Text Language Code: eng
• Subject Heading: hepatocellular carcinoma; hepatic progenitor cell; epithelial cell adhesion molecule; lectin-reactive α-fetoprotein; des-γ-carboxy prothrombin
• Note (General): The high heterogeneity of hepatocellular carcinomas (HCCs) complicates stratification of HCC patients for treatment. Therefore, it is necessary to establish a comprehensive panel of HCC biomarkers related to tumour behaviour and cancer prognosis. Resected HCCs from 251 patients were stained for hepatic progenitor cell (HPC) markers epithelial cell adhesion molecule (EpCAM), neural cell adhesion molecule (NCAM), delta-like 1 homolog (DLK1), and cytokeratin 19 (CK19). Staining patterns were analysed for their prognostic association with relapse-free survival and overall survival. α-Fetoprotein (AFP), lectin-reactive α-fetoprotein (AFP-L3), and des-γ-carboxy prothrombin (DCP) were assessed as indicators of HPC protein expression. Expression pattern of HPC markers correlated with tumour malignancy indicated by high AFP/AFP-L3 serum levels, more frequent vascular invasion, and poorer tumour differentiation. EpCAM expression, DCP ≥300 mAU/ml, age ≥60, and Child-Pugh score grade B or C were independent prognostic factors of poor outcome and were used in a new scoring system for HCC prognosis after operation. Expression of two or more HPC markers was a significant predictor of poor HCC outcome and serum levels of AFP/AFP-L3 correlated with the expression of HPC proteins. Our study paved the way for further elucidation of the association among HPC markers, serum tumour markers, and HCC clinical outcome for precision medicine.; 学位の種類: 博士（医学）. 報告番号: 甲第4492号. 学位記番号: 新大院博（医）甲第829号. 学位授与年月日: 平成30年9月20日; Oncotarget. 2018, 9(31), 21844-21860.; 新大院博（医）甲第829号; 元資料の権利情報 : Seino et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
• DOI: info:doi/10.18632/oncotarget.25074; https://doi.org/info:doi/10.18632/oncotarget.25074
• Persistent ID (NDL): info:ndljp/pid/11217061; https://dl.ndl.go.jp/pid/11217061
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• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-01-04T08:16:43+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
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• Periodical Title (URI): http://hdl.handle.net/10191/50771
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp