Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes

• Material Type: 博士論文
• Title: Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes
• Author/Editor: Hoshino, Yoshifumi
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-09-20
• Publication Date (W3CDTF): 2018-09-20
• Alternative Title: Effect of inhaled corticosteroids on bronchial asthma in Japanese athletes; 日本人アスリート喘息における吸入ステロイドの効果
• Degree grantor/type: 新潟大学
• Date Granted: 2018-09-20
• Date Granted (W3CDTF): 2018-09-20
• Dissertation Number: 乙第2228号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第2228号
• Text Language Code: eng
• Subject Heading: Bronchial provocation test; Fraction of exhaled NO; IgE; Inhaled corticosteroid; Pulmonary function testing
• Note (General): Background: Asthma has a higher prevalence in athlete populations such as Olympic athletes than in the general population. Correct diagnosis and management of asthma in athletes is important for symptom control and avoidance of doping accusations. However, few reports are available on asthma treatment in the athlete population in clinical practice. In this study, we focused on the clinical efficacy of inhaled corticosteroid (ICS) for asthma in a Japanese athlete population. Methods: The study subjects included athletes who visited the Niigata Institute for Health and Sports Medicine, Niigata, Japan for athletic tests and who were diagnosed with asthma on the basis of respiratory symptoms and positive results in a bronchodilator or bronchial provocation test such as exercise, hypertonic saline, or methacholine provocation. The athletes received ICS alone for at least 3 months, and the clinical background, sports type, and treatment efficacy were analyzed. Results: The study population comprised 80 athletes (59 men and 21 women) with a median age of 16.0 years. Regarding sports type, 28 athletes engaged in winter sports (35%), 22 in endurance sports (27.5%), and 25 in indoor sports (31.3%). Although ICS is the primary treatment in athlete asthma, 16.3% of the athletes showed an unsatisfactory response to treatment according to the Global Evaluation of Treatment Effectiveness (GETE). These subjects were characterized by a decreased response to methacholine and lower values for FEV_1/FVC and type 2 helper T cell (Th2)-associated biomarkers relative to responsive athletes. In multivariate analysis, FEV_1/FVC and the logarithm to the base 10 of the IgE level were independently associated with the ICS response. Conclusions: These data suggest that ICS is effective for asthma in most athletes. However, certain asthmatic athletes are less responsive to ICS than expected. The pathogenesis in these subjects may differ from that of conventional asthma characterized by chronic allergic airway inflammation.; 学位の種類: 博士（医学）. 報告番号: 乙第2228号. 学位記番号: 新大博（医）乙第1800号. 学位授与年月日: 平成30年9月20日; Allergology International. 2015, 64(2), 145-149.; 新大博（医）乙第1800号
• DOI: info:doi/10.1016/j.alit.2014.10.004; https://doi.org/info:doi/10.1016/j.alit.2014.10.004
• Persistent ID (NDL): info:ndljp/pid/11217065; https://dl.ndl.go.jp/pid/11217065
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-01-04T08:16:43+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/50775
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp