Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice

• Material Type: 博士論文
• Title: Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice
• Author/Editor: Yamagishi, Tatsuya
• Publication, Distribution, etc.: 新潟大学
• Publication Date: 2018-09-20
• Publication Date (W3CDTF): 2018-09-20
• Alternative Title: Molecular diversity of clustered protocadherin-α required for sensory integration and short-term memory in mice; クラスター型プロトカドヘリンαの分子多様性に依存するマウス感覚統合機能と短期記憶
• Degree grantor/type: 新潟大学
• Date Granted: 2018-09-20
• Date Granted (W3CDTF): 2018-09-20
• Dissertation Number: 甲第4497号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第4497号
• Text Language Code: eng
• Note (General): Clustered protocadherins (Pcdhs) are neuronal cell adhesion molecules characterized by hemophilic adhesion between the tetramers of 58 distinct isoforms in mice. The diversity of Pcdhs and resulting highly-specific neuronal adhesion may be required for the formation of neural circuits for executing higher brain functions. However, this hypothesis remains to be tested, because knockout of Pcdh genes produces abnormalities that may interfere with higher brain functions indirectly. In Pcdh-α1,12 mice, only α1, α12 and two constitutive isoforms are expressed out of 14 isoforms. The appearance and behavior of Pcdh-α1,12 mice are similar to those of wild-type mice, and most abnormalities reported in Pcdh-α knockout mice are not present in Pcdh-α1,12 mice. We examined Pcdh-α1,12 mice in detail, and found that cortical depression induced by sensory mismatches between vision and whisker sensation in the visual cortex was impaired. Since Pcdh-α is densely distributed over the cerebral cortex, various types of higher function are likely impaired in Pcdh-α1,12 mice. As expected, visual short-term memory of space/shape was impaired in behavioral experiments using space/shape cues. Furthermore, behavioral learning based on audio-visual associative memory was also impaired. These results indicate that the molecular diversity of Pcdh-α plays essential roles for sensory integration and short-term memory.; 学位の種類: 博士（医学）. 報告番号: 甲第4497号. 学位記番号: 新大院博（医）甲第834号. 学位授与年月日: 平成30年9月20日; Scientific Reports. 2018, 8, 9616.; 新大院博（医）甲第834号
• DOI: info:doi/10.1038/s41598-018-28034-4; https://doi.org/info:doi/10.1038/s41598-018-28034-4
• Persistent ID (NDL): info:ndljp/pid/11217070; https://dl.ndl.go.jp/pid/11217070
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-01-04T08:16:43+09:00
• Date Created (W3CDTF): 2019-09-10
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
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• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10191/50781
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp