Effects of anesthetic agents on in vivo axonal HCN current in normal mice

Persistent ID (NDL): info:ndljp/pid/11217192

Material type: 博士論文

Author: Osaki, Yusukeほか

Publisher: Elsevier

Publication date: 2015-01-19

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: Objective: The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability.Methods: Normal male mice were anesthe...

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Material Type: 博士論文
ISSN: 1388-2457
Title: Effects of anesthetic agents on in vivo axonal HCN current in normal mice
Volume: 126 10
Author/Editor: Osaki, Yusuke
Nodera, Hiroyuki
Banzrai, Chimeglkham
Endo, Sachiko
Takayasu, Hirokazu
Mori, Atsuko
Shimatani, Yoshimitsu
Kaji, Ryuji
Author Heading: Osaki, Yusuke
Nodera, Hiroyuki
Banzrai, Chimeglkham
Endo, Sachiko
Takayasu, Hirokazu
Mori, Atsuko
Shimatani, Yoshimitsu
Kaji, Ryuji
Publication, Distribution, etc.: Elsevier
Publication Date: 2015-01-19
Publication Date (W3CDTF): 2015-01-19
Alternative Title: 正常マウスにおける軸索HCN電流へ麻酔薬が及ぼす影響
Periodical title: Clinical Neurophysiology
Degree grantor/type: 徳島大学
Date Granted: 2018-09-13
Date Granted (W3CDTF): 2018-09-13
Dissertation Number: 甲第3207号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3207号
Text Language Code: eng
Subject Heading: Axonal excitability
Anesthetics
HCN channel
Target Audience: 一般
Note (General): Objective: The objective was to study the in vivo effects of anesthetic agents on peripheral nerve excitability.Methods: Normal male mice were anesthetized by either isoflurane inhalation or a combination of medetomidine, midazolam, and butorphanol intraperitoneal injection (‘‘triple agents’’). Immediately after induction, the tail sensory nerve action potential was recorded and its excitability was monitored.Results: Under both anesthetic protocols, there was an interval excitability change by long hyperpolarizing currents. There was greater threshold reduction approximately 30 min post induction, in comparison to immediately post induction. Other excitability parameters were stable over time. Modeling suggested interval suppression of internodal H conductance or leak current.Conclusions: Anesthetic agents affected responses to long hyperpolarizing currents. Significance: Axonal excitability during intraoperative monitoring may be affected by anesthetic agents. Interpretation of interval excitability changes under anesthesia requires caution, especially with long hyperpolarizing currents.
DOI: info:doi/10.1016/j.clinph.2014.12.025
https://doi.org/info:doi/10.1016/j.clinph.2014.12.025
Persistent ID (NDL): info:ndljp/pid/11217192
https://dl.ndl.go.jp/pid/11217192
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-01-04T08:16:43+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
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Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/112753
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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