High phosphate diet suppresses lipogenesis in white adipose tissue

• Material Type: 博士論文
• ISSN: 1880-5086
• Title: High phosphate diet suppresses lipogenesis in white adipose tissue
• Volume: 63 3
• Author/Editor: Imi, Yukiko; Yabiki, Norie; Abuduli, Maerjianghan; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Author Heading: Imi, Yukiko; Yabiki, Norie; Abuduli, Maerjianghan; Masuda, Masashi; Yamanaka-Okumura, Hisami; Taketani, Yutaka
• Publication, Distribution, etc.: SOCIETY FOR FREE RADICAL RESEARCH JAPAN
• Publication Date: 2018-11-01
• Publication Date (W3CDTF): 2018-11-01
• Alternative Title: 高リン食は白色脂肪組織の脂肪合成を抑制する
• Periodical title: Journal of Clinical Biochemistry and Nutrition
• Degree grantor/type: 徳島大学
• Date Granted: 2018-03-23
• Date Granted (W3CDTF): 2018-03-23
• Dissertation Number: 甲第3150号
• Degree Type: 博士（栄養学）
• Conferring No. (Dissertation): 甲第3150号
• Text Language Code: eng
• Subject Heading: dietary phosphate; white adipose tissue; insulin; lipogenesis; lipolysis
• Target Audience: 一般
• Note (General): Excessive phosphate intake has been positively associated with renal and vascular dysfunction, conversely negatively associated with body fat accumulation. We investigated the effect of a high-phosphate diet on the expression of lipid metabolic genes in white adipose tissue and liver. Male 8-week-old Sprague–Dawley rats were fed a control diet containing 0.6% phosphate or a high-phosphate diet containing 1.5% phosphate for 4 weeks. In comparison to the control group, the HP group showed a significantly lower body fat mass and fasting plasma insulin level alongside decreased lipogenic and increased lipolytic gene expression in visceral fat. Additionally, the expression of genes involved in hepatic lipogenesis, hepatic glycogenesis, and triglyceride accumulation decreased in the high-phosphate group. Exogenous phosphate, parathyroid hormone, and fibroblast growth factor 23 did not directly affect the expression of lipolytic or lipogenic genes in 3T3-L1 adipocytes and HepG2 hepatocytes. Thus, the high-phosphate diet suppressed the activity of white adipose tissue by increasing lipolytic gene expression and decreasing lipogenic gene expression. These effects could have been caused by the lowered fasting plasma insulin level that occurred in response to the high-phosphate diet, but were not directly caused by the increases in plasma phosphate or phosphaturic hormones.
• DOI: info:doi/10.3164/jcbn.17-141; https://doi.org/info:doi/10.3164/jcbn.17-141
• Persistent ID (NDL): info:ndljp/pid/11239038; https://dl.ndl.go.jp/pid/11239038
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-02-03T04:35:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111624
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp