Is the linear-quadratic model appropriate for stereotactic irradiation of metastatic brain tumors?

• Material Type: 博士論文
• ISSN: 1345-0069
• Title: Is the linear-quadratic model appropriate for stereotactic irradiation of metastatic brain tumors?
• Volume: 69 1,2,3
• Author/Editor: Yoshimine, Tadashi; Fujitani, Nobumasa; Ikeguchi, Toshitaka; Iwami, Hiroshi; Matsuda, Ryosuke; Tamamoto, Tetsuro; Morimoto, Yoko; Hasegawa, Masatoshi
• Author Heading: Yoshimine, Tadashi; Fujitani, Nobumasa; Ikeguchi, Toshitaka; Iwami, Hiroshi; Matsuda, Ryosuke; Tamamoto, Tetsuro; Morimoto, Yoko; Hasegawa, Masatoshi
• Publication, Distribution, etc.: 奈良医学会
• Publication Date: 2018-06-30; 69 1,2,3
• Publication Date (W3CDTF): 2018-06-30
• Alternative Title: L-Qモデルは転移性脳腫瘍の定位放射線照射に適用可能か?
• Periodical title: Journal of Nara Medical Association
• Degree grantor/type: 奈良県立医科大学
• Date Granted: 2018-09-26
• Date Granted (W3CDTF): 2018-09-26
• Dissertation Number: 甲第688号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 甲第688号
• Text Language Code: eng
• Subject Heading: LQ model; BED; stereotactic irradiation; SRS; SRT
• Target Audience: 一般
• Note (General): type:Thesis; The biologically effective dose (BED) based on the linear-quadratic (LQ) model has been commonly used to evaluate the dose-effect relationships among the different fractionation schedules, but whether the LQ model is appropriate for hypofractionated (HF) high-dose stereotactic irradiation (STI) is uncertain. The validity of the model at high doses per fraction has been critically examined. In this study, STI of metastatic brain tumors was evaluated to suggest the applicability of the LQ model to HF high-dose radiotherapy. No significant difference was found between stereotactic radiosurgery (SRS) and HF stereotactic radiotherapy (SRT) in the analyses of 151 tumors. Furthermore, no significant differences were found among SRS, HF-SRT, and non-HF SRT in 117 metastatic lung adenocarcinomas. The results of this study suggest that BED calculation is a reasonable approach for careful dose-effect evaluation based on the LQ model for HF high-dose radiotherapy for metastatic brain tumors, especially lung adenocarcinomas.; 博士（医学）・甲第688号・平成30年9月26日; identifier:Journal of Nara Medical Association Vol.69 No.1,2,3 p.9-15 (2018.6); identifier:13450069; identifier:http://ginmu.naramed-u.ac.jp/dspace/handle/10564/3496; identifier:Journal of Nara Medical Association, 69(1,2,3): 9-15
• Persistent ID (NDL): info:ndljp/pid/11239127; https://dl.ndl.go.jp/pid/11239127
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-02-03T04:35:56+09:00
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10564/3496
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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