A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer

Persistent ID (NDL): info:ndljp/pid/11245924

Material type: 博士論文

Author: Daizumoto, Keiほか

Publisher: American Association for Cancer Research

Publication date: 2018-02-13

Material Format: Digital

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Name of awarding university/degree: 徳島大学,博士（医学）

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Note (General)：: The p53 and EGFR pathways are frequently altered in bladder cancers, yet their contributions to its progression remain elusive. Here we report that DE...

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Material Type: 博士論文
ISSN: 0008-5472
Title: A DDX31/mutant-p53/EGFR axis promotes multistep progression of muscle invasive bladder cancer
Volume: 78 9
Author/Editor: Daizumoto, Kei
Yoshimaru, Tetsuro
Matsushita, Yosuke
Fukawa, Tomoya
Uehara, Hisanori
Ono, Masaya
Komatsu, Masato
Kanayama, Hiro-omi
Katagiri, Toyomasa
Author Heading: Daizumoto, Kei
Yoshimaru, Tetsuro
Matsushita, Yosuke
Fukawa, Tomoya
Uehara, Hisanori
Ono, Masaya
Komatsu, Masato
Kanayama, Hiro-omi
Katagiri, Toyomasa
Publication, Distribution, etc.: American Association for Cancer Research
Publication Date: 2018-02-13
Publication Date (W3CDTF): 2018-02-13
Alternative Title: DDX31/p53変異/EGFR経路は筋層浸潤膀胱癌の多段階進展を促進する
Critical roles of DDX31-mutp53-EGFR axis in MIBC progression
Periodical title: Cancer Research
Degree grantor/type: 徳島大学
Date Granted: 2018-04-26
Date Granted (W3CDTF): 2018-04-26
Dissertation Number: 甲第3194号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第3194号
Text Language Code: eng
Subject Heading: DDX31
mutant-p53
EGFR
muscle invasive bladder cancer
Target Audience: 一般
Note (General): The p53 and EGFR pathways are frequently altered in bladder cancers, yet their contributions to its progression remain elusive. Here we report that DEAD box polypeptide 31 (DDX31) plays a critical role in the multistep progression of muscle invasive bladder cancer (MIBC) through its sequential interactions with mutant p53 (mutp53) and EGFR. In early MIBC cells, nuclear DDX31 bound mutp53/SP1 and enhanced mutp53 transcriptional activation, leading to migration and invasion of MIBC. Cytoplasmic DDX31 also bound EGFR and phospho-nucleolin (p-NCL) in advanced MIBC, leading to EGFR-Akt signaling activation. High expression of both cytoplasmic DDX31 and p53 proteins correlated with poor prognosis in patients with MIBC, and blocking the DDX31-NCL interaction resulted in downregulation of EGFR-Akt signaling, eliciting an in vivo anti-tumor effect against bladder cancer. These findings reveal that DDX31 cooperates with mutp53 and EGFR to promote progression of MIBC, and inhibition of DDX31-NCL formation may lead to potential treatment strategies for advanced MIBC.
DOI: info:doi/10.1158/0008-5472.CAN-17-2528
https://doi.org/info:doi/10.1158/0008-5472.CAN-17-2528
Persistent ID (NDL): info:ndljp/pid/11245924
https://dl.ndl.go.jp/pid/11245924
Collection: 障害者向け資料
Collection (Materials For Handicapped People:1): テキストデータ
Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
Format (IMT): application/pdf
Access Restrictions: 国立国会図書館内限定公開
Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
Availability of remote photoduplication service: 可
Periodical Title (URI): http://repo.lib.tokushima-u.ac.jp/111804
Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション
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