CO₂ laser therapy accelerates the healing of ulcers in the oral mucosa by inducing the expressions of heat shock protein-70 and tenascin C.

• Material Type: 博士論文
• Title: CO₂ laser therapy accelerates the healing of ulcers in the oral mucosa by inducing the expressions of heat shock protein-70 and tenascin C.
• Author/Editor: Gang, Luo; Oka, Kyoko; Ohki, Shirabe; Rikitake, Mihoko; Itaya, Satoshi; Tamura, Shougo; Toda-Nakamura, Masako; Ogata, Kayoko; Kira-Tatsuoka, Michiko; Ozaki, Masao
• Author Heading: Gang, Luo; Oka, Kyoko; Ohki, Shirabe; Rikitake, Mihoko; Itaya, Satoshi; Tamura, Shougo; Toda-Nakamura, Masako; Ogata, Kayoko; Kira-Tatsuoka, Michiko; Ozaki, Masao
• Publication Date: 2018-09-27
• Publication Date (W3CDTF): 2018-09-27
• Alternative Title: CO₂ laser therapy accelerates the healing of ulcers in the oral mucosa by inducing the expressions of heat shock protein-70 and tenascin C.
• Degree grantor/type: 福岡歯科大学
• Date Granted: 2018-09-27
• Date Granted (W3CDTF): 2018-09-27
• Dissertation Number: 甲第302号
• Degree Type: 博士（歯学）
• Conferring No. (Dissertation): 甲第302号
• Text Language Code: eng
• Subject Heading: CO2 レーザー; 創傷治癒; テネイシンC; ヒートショック蛋白70; 温度; CO2 laser; wound healing; tenascin C; heat shock protein-70; temperature
• Target Audience: 一般
• Note (General): The treatment of ulceration or stomatitis with laser therapy is known to accelerate healing and relieve pain, but the underlying biological mechanism is not fully understood. The present study used a mouse model of ulceration to investigate the molecular mechanisms by which CO₂ laser therapy accelerated the wound healing process. An ulcer was experimentally created in the palatal mucosa of the mouse and irradiated with light from a CO₂ laser. Compared with controls (no irradiation), laser irradiation induced the proliferation of epithelial cells and faster re-epithelialization of the wound area. Immunohistochemistry experiments showed that heat shock protein-70 (HSP70) was expressed mainly in the epithelium of normal palatal tissue, whereas there was little tenascin C (TnC) expression in the epithelium and mesenchyme under normal conditions. Laser irradiation induced HSP70 mRNA and protein expression in the lamina propria as well as TnC expression in the mesenchyme underlying the renewing epithelium. Epithelial cells and fibroblasts were exposed to heated culture medium or laser irradiation to establish whether hyperthermia mimicked the effect of laser irradiation. Culture of fibroblasts in heated medium increased the expressions of both TnC and TGF-β1, whereas laser irradiation induced only TnC expression. The present study indicates that CO₂ laser irradiation exerts a photobiogenic effect to up-regulate TnC expression without inducing TGF-β1 expression. We suggest that CO₂ laser therapy has an advantage over thermal stimulation.; Histology and histopathology
• Persistent ID (NDL): info:ndljp/pid/11246156; https://dl.ndl.go.jp/pid/11246156
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
• Date Created (W3CDTF): 2019-02-07
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://doi.org/10.14670/HH-18-037
• Periodical Title (URI): https://fdc.repo.nii.ac.jp/records/97
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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