Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells

• Material Type: 博士論文
• Title: Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells
• Author/Editor: 扇谷, 昌宏
• Author Heading: 扇谷, 昌宏
• Publication Date: 2018-10-31
• Publication Date (W3CDTF): 2018-10-31
• Alternative Title: 線維筋痛症とミクログリア由来TNF-α：ヒト末梢血誘導ミクログリア様細胞を用いた橋渡し研究
• Contributor: 吉良, 潤一; 岩城, 徹; 新納, 宏昭
• Degree grantor/type: 九州大学
• Date Granted: 2018-10-31
• Date Granted (W3CDTF): 2018-10-31
• Dissertation Number: 乙第08751号
• Degree Type: 博士（医学）
• Conferring No. (Dissertation): 乙第08751号
• Text Language Code: eng
• Target Audience: 一般
• Note (General): Fibromyalgia is a refractory disease characterized by chronic intractable pain and psychological suffering, the cause of which has not yet been elucidated due to its complex pathology. Activation of immune cells in the brain called microglia has attracted attention as a potential underlying pathological mechanism in chronic pain. Until recently, however, technological and ethical considerations have limited the ability to conduct research using human microglia. To overcome this limitation, we have recently developed a technique to create human-induced microglia-like (iMG) cells from human peripheral blood monocytes. In this study, we created the iMG cells from 14 patients with fibromyalgia and 10 healthy individuals, and compared the activation of iMG cells between two groups at the cellular level. The expression of tumor necrosis factor (TNF)-α at mRNA and protein levels significantly increased in ATP-stimulated iMG cells from patients with fibromyalgia compared to cells from healthy individuals. Interestingly, there was a moderate correlation between ATP-induced upregulation of TNF-α expression and clinical parameters of subjective pain and other mental manifestations of fibromyalgia. These findings suggest that microglia in patients with fibromyalgia are hypersensitive to ATP. TNF-α from microglia may be a key factor underlying the complex pathology of fibromyalgia.; PubMed番号 : 28928366
• DOI: info:doi/10.1038/s41598-017-11506-4; https://doi.org/info:doi/10.1038/s41598-017-11506-4
• Persistent ID (NDL): info:ndljp/pid/11246161; https://dl.ndl.go.jp/pid/11246161
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
• Date Created (W3CDTF): 2019-02-12
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/2324/2198526
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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