Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study

• Material Type: 博士論文
• Title: Dysfunction of ventrolateral prefrontal cortex underlying social anxiety disorder: A multi-channel NIRS study
• Author/Editor: Yokoyama, Chika
• Author Heading: Yokoyama, Chika
• Publication, Distribution, etc.: 三重大学
• Publication Date: 2018-09-19
• Publication Date (W3CDTF): 2018-09-19
• Degree grantor/type: 三重大学
• Date Granted: 2018-09-19
• Date Granted (W3CDTF): 2018-09-19
• Dissertation Number: 乙医学第1021号
• Degree Type: 博士(医学)
• Conferring No. (Dissertation): 乙医学第1021号
• Text Language Code: eng
• Alias of Author: ヨコヤマ, チカ; 横山, 知加; 葛島, 知加
• Subject Heading: Social anxiety disorder; Ventrolateral prefrontal cortex; Emotion; Near-infrared spectroscopy (NIRS)
• Target Audience: 一般
• Note (General): application/pdf; Social anxiety disorder (SAD) is characterized by strong fear and anxiety during social interactions. Although ventrolateral prefrontal cortex (VLPFC) activity in response to emotional stimuli is related to pathological anxiety, little is known about the relationship between VLPFC activity and social anxiety. This study aimed to investigate whether VLPFC activity was involved in SAD and whether VLPFC activity was related to the level of social anxiety. Twenty-four drug-naïve patients with SAD and 35 healthy controls underwent near-infrared spectroscopy (NIRS) scanning while performing a verbal fluency task (VFT). Results indicated that, compared to the healthy controls, the SAD patients exhibited smaller changes of oxygenated hemoglobin (oxy-Hb) concentrations in the VLPFC during the VFT. Furthermore, the right VLPFC activation was negatively correlated with social avoidance. In contrast to the latter, the healthy controls exhibited a positive correlation between changes of oxy-Hb concentrations in the bilateral VLPFC and social fear. Our findings provide evidence for VLPFC dysfunction in SAD, and indicate that the VLPFC dysfunction may contribute to the difference between normal and abnormal social anxiety.; 本文 / Department of Psychiatry, Division of Neuroscience, Graduate School of Medicine, Mie University, Mie, Japan.; 7p
• DOI: info:doi/10.1016/j.nicl.2015.05.011; https://doi.org/info:doi/10.1016/j.nicl.2015.05.011
• Persistent ID (NDL): info:ndljp/pid/11246244; https://dl.ndl.go.jp/pid/11246244
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-03-03T03:58:25+09:00
• Date Created (W3CDTF): 2019-02-19
• Format (IMT): application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Periodical Title (URI): http://hdl.handle.net/10076/00017931; https://mie-u.repo.nii.ac.jp/records/12299
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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2023-12-15 再収集