ホスホリルコリン舌下ならびに経鼻免疫に対する粘膜および全身免疫応答

• Material Type: 博士論文
• Title: ホスホリルコリン舌下ならびに経鼻免疫に対する粘膜および全身免疫応答
• Volume: 45 2
• Author/Editor: 間世田, 佳子
• Author Heading: 間世田, 佳子
• Publication, Distribution, etc.: Elsevier
• Publication Date: 2018; 45 2
• Publication Date (W3CDTF): 2018
• Alternative Title: Mucosal and systemic immune response to sublingual or intranasal immunization with phasphorylcholine
• Periodical title: Auris Nasus Larynx
• Degree grantor/type: 鹿児島大学
• Date Granted: 2019-02-26
• Date Granted (W3CDTF): 2019-02-26
• Dissertation Number: 乙総論第34号
• Degree Type: 博士(医学); Doctor of Philosophy in Medical Science
• Conferring No. (Dissertation): 乙総論第34号
• Text Language Code: eng
• Subject Heading: Phosphorylcholine; Sublingual; Intranasal; Streptococcus pneumoniae; Non-typeable Haemophilus influenzae; Immunoglobulin E
• NDC: 491
• Target Audience: 一般
• Note (General): 博士論文全文, 最終試験結果の要旨, 論文審査の要旨, 博士論文要旨; Objective: Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Here, the immune response in mice to PC immunization via the sublingual (SL) route versus the intranasal (IN) route was investigated in terms of efficacy and safety.Methods: BALB/c mice were immunized with PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT) or CT alone via the IN or SL route. The immune response generated was studied in terms of PC-specific antibody titers, interferon (IFN)-g and interleukin (IL)-4 production by CD4+ T cells, and cross-reactivity of PC-specific immunoglobulin (Ig)-A antibodies in nasal washes against S. pneumoniae and non-typeable H. influenzae.Results: SL and IN immunization with PC-KLH plus CT resulted in a marked increase in the levels of PC-specific, mucosal IgA and serum IgM, IgG, and IgA antibodies. Additionally, SL immunization elicited significantly higher levels of PC-specific IgG2a subclass antibodies and IFNg in serum. On the other hand, IN immunization with CT alone remarkably increased the total IgE level in serum compared with SL and IN immunization with PC-KLH plus CT. PC-specific IgA antibodies in nasal wash samples reacted to most strains of S. pneumoniae and non-typeable H. influenzae.Conclusion: SL immunization is as effective as IN immunization to induce PC-specific immune responses and more effective than IN immunization to reduce the production of IgE and to prevent the sensitization to allergen causing type I allergy.
• DOI: info:doi/10.1016/j.anl.2017.04.009; https://doi.org/info:doi/10.1016/j.anl.2017.04.009
• Persistent ID (NDL): info:ndljp/pid/11278484; https://dl.ndl.go.jp/pid/11278484
• Collection: 障害者向け資料
• Collection (Materials For Handicapped People:1): テキストデータ
• Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文; https://dl.ndl.go.jp/collections/A00014
• Acquisition Basis: 博士論文（自動収集）
• Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
• Date Created (W3CDTF): 2019-03-01
• Format (IMT): PDF; application/pdf
• Access Restrictions: 国立国会図書館内限定公開
• Service for the Digitized Contents Transmission Service: 図書館・個人送信対象外
• Availability of remote photoduplication service: 可
• Original Material (URI): https://www.sciencedirect.com/journal/auris-nasus-larynx
• Periodical Title (URI): http://hdl.handle.net/10232/00030438
• Data Provider (Database): 国立国会図書館 : 国立国会図書館デジタルコレクション; https://dl.ndl.go.jp

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