Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets

Persistent ID (NDL): info:ndljp/pid/11278721

Material type: 博士論文

Author: 中村, 信

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Publication date: 2015-06-25

Material Format: Digital

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Name of awarding university/degree: 香川大学,博士（医学）

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Note (General)：: AbstractThe aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near‐infrared time‐resolved spectrosc...

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Material Type: 博士論文
Title: Cerebral blood volume measurement using near-infrared time-resolved spectroscopy and histopathological evaluation after hypoxic-ischemic insult in newborn piglets
Author/Editor: 中村, 信
Author Heading: 中村, 信
Publication Date: 2015-06-25
Publication Date (W3CDTF): 2015-06-25
Degree grantor/type: 香川大学
Date Granted: 2015-06-25
Date Granted (W3CDTF): 2015-06-25
Dissertation Number: 甲第613号
Degree Type: 博士（医学）
Conferring No. (Dissertation): 甲第613号
Text Language Code: eng
Alias of Author: Nakamura, Makoto
Subject Heading: Amplitude‐integrated electroencephalography
Animal model
Brain histology
Cerebral blood volume
Near‐infrared spectroscopy
Hypoxia‐ischemia
Target Audience: 一般
Note (General): AbstractThe aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near‐infrared time‐resolved spectroscopy (TRS) and pathological change of the brain in a hypoxic‐ischemic (HI) piglet model.Twenty‐one anesthetized newborn piglets, including three sham controls, were studied. An HI event was induced by low inspired oxygen. CBV was measured using TRS (Hamamatsu TRS‐10). Data were collected before, during, and 6 h after the insult. CBV was calculated as the change from the end of the insult. The piglets were allowed to recover from anesthesia for 6 h after the insult. At the age of 5 days, the brains of the piglets were perfusion‐fixed, and histologic evaluations of brain tissue were performed. The extent of histopathological damage was graded in 0.5‐unit intervals on a 9‐step scale.CBV increments were well correlated with histopathological scores, especially at 1 and 3 h after resuscitation. Spearman's rank‐correlation coefficients at 1, 3, and 6 h after resuscitation in the gray matter were 0.9016, 0.9127, and 0.6907, respectively.We conclude that an increased CBV after HI insult indicates more marked histological brain damage. CBV measurement immediately after resuscitation provides a more precise prediction of the histological outcome.
DOI: info:doi/10.1016/j.ijdevneu.2015.02.009
https://doi.org/info:doi/10.1016/j.ijdevneu.2015.02.009
Persistent ID (NDL): info:ndljp/pid/11278721
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Collection: 障害者向け資料
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Collection (particular): 国立国会図書館デジタルコレクション > デジタル化資料 > 博士論文
https://dl.ndl.go.jp/collections/A00014
Acquisition Basis: 博士論文（自動収集）
Date Accepted (W3CDTF): 2019-05-06T10:27:56+09:00
Date Created (W3CDTF): 2020-10-27
Format (IMT): PDF
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Periodical Title (URI): https://kagawa-u.repo.nii.ac.jp/records/348
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